3.2.1. High Quality of Evidence

Neuroprotective agents had little to no effect versus placebo on late seizures 6 months after the start of treatment in moderate-to-severe TBI in participants aged 14 and older (1 study; *n* = 498) [25].

#### 3.2.2. Moderate Quality of Evidence

Phenytoin likely resulted in no changes in late seizures 6 to 24 months after the start of the treatment relative to other antiepileptic drugs in moderate-to-severe TBI (2 studies; *n* = 378) [25].
