**5. Conclusions**

Evaluation of PET/CT scans using (semi-)quantitative measures such as SUVs should be performed with grea<sup>t</sup> caution, as SUVs are influenced by scanning and reconstruction parameters. Based on the evaluation of multiple reconstructions with different β of phantom scans, an intermediate β (600) is suggested as the optimal value for the reconstruction of clinical 68Ga-PSMA PET/CT scans, considering that both detectability and reproducibility are relevant.

**Author Contributions:** Conceptualization, S.R., M.J.R., A.J.A.; methodology, S.R., M.J.R., A.J.A.; formal analysis, S.R.; writing—original draft preparation, S.R., M.J.R., A.J.A.; writing—review and editing, S.R., M.J.R., A.J.A.; visualization, S.R.; All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** The data presented in this study are available on request from the corresponding author.

**Conflicts of Interest:** The authors declare no conflict of interest.
