*Article* **Ellagitannin, Phenols, and Flavonoids as Antibacterials from** *Acalypha arvensis* **(Euphorbiaceae)**

**Ever A. Ble-González 1,\*, Abraham Gómez-Rivera <sup>1</sup> , Alejandro Zamilpa <sup>2</sup> , Ricardo López-Rodríguez <sup>1</sup> , Carlos Ernesto Lobato-García 1 , Patricia Álvarez-Fitz <sup>3</sup> , Ana Silvia Gutierrez-Roman <sup>2</sup> , Ma Dolores Perez-García 2 , Alejandro Bugarin <sup>4</sup> and Manasés González-Cortazar 2,\***


**Abstract:** There is a significant need to gain access to new and better antibacterial agents. *Acalypha arvensis,* a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of *Acalypha arvensis.* Specifically, three extracts were assessed (*n*-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant *Staphylococcus aureus*, *Klebsiella pneumoniae,* and *Pseudomonas aeruginosa* strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (**1**) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (**2**), rutin (**3**), quercetin-3-*O*-glucoside (**4**), caffeic acid (**5**), among others (**6**–**8**). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.

**Keywords:** *Acalypha arvensis*; ellagitannin; corilagin; *Staphylococcus aureus*; flavonoids; antibacterial
