*3.1. New Azaphilone Compounds*

Two complementary reviews cover a good part of literature about azaphilones from 1932 to 2019. Gao et al. [30] reviewed literature from end of 1932 to September 2012, reporting data on 373 azaphilones of 18 categories and Chen et al. [31] published data on the chemistry and biology of azaphilones, covering 252 compounds predominantly originated from 32 genera of fungi reported between October 2012 to December 2019 [31]. Naturallyderived azaphilones reported by Chen et al. [31] were classified in 13 types: nitrogenated, citrinins, austdiols, deflectins, bulgariolactones, spiro-azaphilones, O-substituted, lactone, hydrogenated, chaetovirins, pulvilloric acid, sclerotiorins, and cohaerins. Azaphilone pigments of atrorosin class produced by *Talaromyces atroroseus* were reviewed by Isbrandt et al. [32], and Morales-Oyervides et al. [11] reviewed natural colorants produced by fungi from *Talaromyces*/*Penicillium* genus [11].

In this section, it is presented a summary of the new compounds reported after December 2019 classified according to the fungal genera source. Despite the great number of 100 new compounds reported from January 2020 to March 2021, the azaphilones were isolated only from nine fungal genera (*Aspergillus*, *Chaetomium*, *Hypoxylon*, *Monascus*, *Muycopron*, *Penicillium*, *Phomopsis*, *Pleosporales,* and *Talaromyces*). The genus *Phomopsis* was not cited in the latest review and now appeared as fungal endophytic sources of chlorinated azaphilone pigments. At this time, it will be presented the new compounds isolated from each genus (Figures 2–9) displayed according to the species (Table 1).
