**2. Materials and Methods**

To carry out this systematic review, a bibliographic search was carried out in the MEDLINE database through PubMed.

The following combinations of keywords were performed: "calcium sulfate" [MeSH Terms] AND ("surgery, oral" [MeSH Terms] OR "oral surgical procedures" [MeSH Terms]), "calcium sulfate" [MeSH Terms] AND "bone regeneration" [MeSH Terms], (calcium sulfate [MeSH Terms]) AND (bone grafting [MeSH Terms]).

The articles that were included in this systematic review had to meet the following inclusion criteria: controlled clinical trials, randomized controlled clinical trials, and case series, with more than 30 participants, carried out in humans and published within the last 10 years in English. Studies outside the field of dentistry, systematic reviews, preclinical studies, and clinical trials with insufficient information were excluded.

Finally, a case series is presented using the calcium sulfate for different procedures. Specifically, with Biphasic calcium sulfate/hydroxyapatite (BCS/HA): BCS-CaSO4·1/2 H2O+CaSO4·2H2O and HA-Ca10(PO4)6(OH)2 and liquid-NaCl 0.9%.

The selected studies were assessed following the SORT criteria [27].
