3.2.2. Antibiotic Drugs

In 2019, Shi et al. reported an infection-responsive membrane that was esterified MNAgrafted PDA functionalized with a siloxane-coated PCL membrane [24]. The ester bonds could be selectively hydrolyzed by cholesterol esterase (CE) secreted by macrophagocytes accumulated at the site of infection. Thus, the membrane was designed in a manner that increases the CE concentration due to severe infection leading to the release of a higher amount of MNA, thereby resulting in an enhanced antibacterial property. In this study, released MNA due to CE from an MNA-grafted PDA-coated membrane exhibited antibacterial activity [24].

The other studies reported Dox-coated membranes with enhanced antibacterial activities [26,43]. Zhao et al. reported porous chitosan/gelatin/Dox-coated Ti-niobium membrane [43]. Lian et al. reported a Dox-modified PLGA membrane [26].

## 3.2.3. Chlorhexidine and Antimicrobial Peptides

In 2020, Boda et al. reported an AMPs- or CHX-loaded oxidized pectin-coated chitosan membrane [44]. The D-enantiomer of GL13K (D-GL13K) derived from the human salivary parotid secretory protein and the L-enantiomer of innate defense regulator—1018 (IDR-1018)—were used as AMPs. CHX, D-GL13K, and IDR-1018 were coated on the membrane via the co-electrospinning method or the surface absorption method. In this study, the AMPs-loaded pectin-coated chitosan membrane showed an antimicrobial property that was comparable to CHX against *Streptococci* [44].
