*2.2. Characteristics of the Study Population*

Female pregnant mice from both control and CM group did not display significant differences in body weight after LPS injection and treatment with unconditioned/conditioned media (CM = median 27.4 g; controls: median 26.3 g). Mice from the control group showed adverse pregnancy outcomes, including fetal absorption (n = 5) and significant lower placental weight (*p* < 0.01), compared with PDMSCs-CM group (Table 1). Moreover, one case of miscarriage was observed in the control group. No significant differences were observed in fetal weight (Table 1).


**Table 1.** Effect of PDMSCs-CM treatment on clinical and biochemical parameters of mice in PDMSCs-CM and control groups.

Significant main effect of PDMSCs-CM treatment on number of fetus, fetal reabsorption, and placental weight. Data are expressed as means ± SEM. ns: not significant.

RBC (red blood cells) and WBC (white blood cells) count, Htc (hematocrit), and hemoglobin concentration did not change between groups but there was a trend of decrease in Plt (platelets) count in control relative to CM-treated mice (Table 1).
