2.2.4. Aspericacids

Aspericacids A (**27**) and B (**28**) were isolated in 2020 by Ding and He from the spongeassociated *Aspergillus* sp. LS78 [29]. Both compounds bear a 2,5-disubstituted tetrahydrofuran ring coupled with an unsaturated fatty acid (Figure 7). Their structure was determined by HRESIMS and 1D and 2D NMR spectroscopy, while their absolute configuration was established relying on electronic circular dichroism (ECD). Compound **27** presents a moderate inhibitory activity against *Candida albicans* and *Cryptococcus neoformans* with a MIC value of 50 μg/mL, although **28** has a weaker activity, MIC = 128 μg/mL. No synthetic approach has been reported to date.

**Figure 7.** Structure of aspericacids A **27** and B **28**.
