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**Table 1.** Overview of compounds from this review, their sources, classes, and species (background color code coincides with that of Figure 1).

We want to offer the reader an overview of the most recent tetrahydrofuran-containing terpenoids and related compounds of marine origin, their natural source of isolation, biological properties, and synthetic strategies towards them. We have also included classic examples, as their structure and activity are closely related to the more recently isolated metabolites and help to understand structure–activity relationships. We start with some examples of fatty acids with interesting biological profiles, and then move to the broad family of terpenoid compounds (monoterpenes, sesquiterpenes, diterpenes, triterpenes, and meroterpenoids). At the end, we also highlight other small THF-containing compounds that show interesting biological activities or were recently isolated and, thus, have potential to be shown in the near future.
