*2.5. Polyhydroxyl*

Amphezonol A

The dinoflagelatte *Amphidinium* sp. has been extensively studied in order to discover and isolate new compounds bearing interesting biological properties, such as macrolides, amphidinolides or polyhydroxyl compounds. In 2006, a novel polyhydroxyl metabolite was isolated, amphenozol A (**172**) [115], the structure of which consists of a C60 linear aliphatic chain with two tetrahydropyran rings, one tetrahydrofuran ring, and twenty-one hydroxyl groups (Figure 25). Its structure was established by NMR experiments. Additionally, the biological analysis showed a modest inhibitory activity against DNA polymerase α.

**Figure 25.** Structure of amphenozol A.
