*Communication* **Synthesis of Thiazolidinedione Compound Library**

**Fehmi Damkaci \*, Adam A. Szymaniak, Jason P. Biasini and Ryan Cotroneo**

> Department of Oswego, SUNY Oswego, Oswego, NY 13126, USA; szymania@oswego.edu (A.A.S.); biasini@oswego.edu (J.P.B.); cotroneo@oswego.edu (R.C.) **\***

 Correspondence: fehmi.damkaci@oswego.edu; Tel.: +1-315-312-2698

**Abstract:** Thiazolidinediones (TZDs), also known as Glitazones, have anti-diabetic, anti-inflammatory and anti-cancer properties. A simple, efficient and cost-effective synthesis of a thiazolidinedione compound library was developed. The synthesis is facilitated by microwave irradiation in three of the four steps followed by reduction under pressurized hydrogen gas using palladium hydroxide. All reactions, except one, were completed within an hour and provided desired products in moderate to good yields after a simple work-up.

**Keywords:** thiazolidinedione; microwave synthesis; compound library; rosiglitazone; Knoevangel condensation
