**4. Conclusions**

In conclusion, we developed a simple, efficient, and cost-effective synthesis of a thiazolidinedione compound library with the use of microwave irradiation and phase transfer catalysis. It should be noted all products were obtained with a simple work-up without column chromatography. Future studies will entail expansion of the compound library, improvements in yield and further biological evaluation of the compounds.

**Supplementary Materials:** https://www.mdpi.com/article/10.3390/compounds2030013/s1, Table S1: 1H and 13C-NMR spectral data for compound **7** derivatives; Table S2: 1H and 13C-NMR spectral data for compound **8** derivatives; Table S3: 1H and 13C-NMR spectral data for compound **9** derivatives; Table S4: 1H and 13C-NMR spectral data for compound **10** derivatives.

**Author Contributions:** Conceptualization, F.D.; methodology development, F.D., A.A.S. and J.P.B.; performing reactions and formal analysis, A.A.S., J.P.B. and R.C.; writing—original draft preparation, J.P.B.; writing—review and editing, F.D.; supervision and project administration, F.D. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable. **Data Availability Statement:** Not applicable.

**Acknowledgments:** The authors gratefully acknowledge SUNY at Oswego for providing the Student Scholarly Creativity and Activity Grant and the Department of Chemistry for providing additional funds. Special thanks to Michael Knopp (The University of Maine at Presque Isle) and to Wataru Kitagawa of AIST Hokkaido for performing the antimicrobial cultures.

**Conflicts of Interest:** The authors declare no conflict of interest.
