*Experimental Diets*

The composition of the FC-like diet was oriented towards the work of Jansen et al. All diets containing PUFAs were stored at −20 ◦C to minimize oxidation [35]. Due to coprophagia (the ingestion of fecal matter) in mice, the vitamin B deficient diet additionally contained the antibiotic sulfathiazole sodium (Sigma-Aldrich, Taufkirchen, Germany) to prevent bacterial folate synthesis in the gu<sup>t</sup> [58]. All experimental diets were purchased from Ssni ff-Spezialdiäten GmbH (Soest, Germany).


**Table A1.** Composition of the experimental diets.
