*Review* **Computational Simulations in Advanced Microfluidic Devices: A Review**

**Violeta Carvalho 1,2,\* , Raquel O. Rodrigues <sup>3</sup> , Rui A. Lima 1,4 and Senhorinha Teixeira <sup>2</sup>**


**Abstract:** Numerical simulations have revolutionized research in several engineering areas by contributing to the understanding and improvement of several processes, being biomedical engineering one of them. Due to their potential, computational tools have gained visibility and have been increasingly used by several research groups as a supporting tool for the development of preclinical platforms as they allow studying, in a more detailed and faster way, phenomena that are difficult to study experimentally due to the complexity of biological processes present in these models—namely, heat transfer, shear stresses, diffusion processes, velocity fields, etc. There are several contributions already in the literature, and significant advances have been made in this field of research. This review provides the most recent progress in numerical studies on advanced microfluidic devices, such as organ-on-a-chip (OoC) devices, and how these studies can be helpful in enhancing our insight into the physical processes involved and in developing more effective OoC platforms. In general, it has been noticed that in some cases, the numerical studies performed have limitations that need to be improved, and in the majority of the studies, it is extremely difficult to replicate the data due to the lack of detail around the simulations carried out.

**Keywords:** computational simulations; drug discovery; organ-on-a-chip; microfluidic devices; preclinical models; numerical simulations
