*Article* **Typical Fluorescent Sensors Exploiting Molecularly Imprinted Hydrogels for Environmentally and Medicinally Important Analytes Detection**

**Lihua Zou 1,†, Rong Ding 2,†, Xiaolei Li <sup>2</sup> , Haohan Miao <sup>3</sup> , Jingjing Xu 1,2,\* and Guoqing Pan 3,\***


**Abstract:** In this work, two typical fluorescent sensors were generated by exploiting molecularly imprinted polymeric hydrogels (MIPGs) for zearalenone (ZON) and glucuronic acid (GA) detection, via the analyte's self-fluorescence property and receptor's fluorescence effect, respectively. Though significant advances have been achieved on MIPG-fluorescent sensors endowed with superior stability over natural receptor-sensors, there is an increasing demand for developing sensing devices with cost-effective, easy-to-use, portable advantages in terms of commercialization. Zooming in on the commercial potential of MIPG-fluorescent sensors, the MIPG\_ZON is synthesized using zearalanone (an analogue of ZON) as template, which exhibits good detection performance even in corn samples with a limit of detection of 1.6 µM. In parallel, fluorescein-incorporated MIPG\_GA is obtained and directly used for cancer cell imaging, with significant specificity and selectivity. Last but not least, our consolidated application results unfold new opportunities for MIPG-fluorescent sensors for environmentally and medicinally important analytes detection.

**Keywords:** molecularly imprinted polymeric hydrogels; synthetic receptors; zearalenone; glucuronic acid; fluorescent sensors
