*Review* **Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)**

**Fa-Lei Zhang and Tao Feng \***

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; flzhang@mail.scuec.edu.cn

**\*** Correspondence: tfeng@mail.scuec.edu.cn

**Abstract:** Fungi have traditionally been a very rewarding source of biologically active natural products, while diterpenoids from fungi, such as the cyathane-type diterpenoids from *Cyathus* and *Hericium* sp., the fusicoccane-type diterpenoids from *Fusicoccum* and *Alternaria* sp., the guanacastane-type diterpenoids from *Coprinus* and *Cercospora* sp., and the harziene-type diterpenoids from *Trichoderma* sp., often represent unique carbon skeletons as well as diverse biological functions. The abundances of novel skeletons, biological activities, and biosynthetic pathways present new opportunities for drug discovery, genome mining, and enzymology. In addition, diterpenoids peculiar to fungi also reveal the possibility of differing biological evolution, although they have similar biosynthetic pathways. In this review, we provide an overview about the structures, biological activities, evolution, organic synthesis, and biosynthesis of diterpenoids that have been specially produced by fungi from 2010 to 2020. We hope this review provides timely illumination and beneficial guidance for future research works of scholars who are interested in this area.

**Keywords:** diterpenes; isolation; structure; biological activity; biosynthesis

**Citation:** Zhang, F.-L.; Feng, T. Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020). *J. Fungi* **2022**, *8*, 244.

https://doi.org/10.3390/jof8030244 Academic Editor: Gary A. Strobel

Received: 25 January 2022 Accepted: 27 February 2022 Published: 28 February 2022

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