2.8.6. PPI Network Analysis

The protein-protein interaction (PPI) network analysis was done using the STRING v11.0 database. The input proteins showed a confidence score of 0.6–0.9. In the first category of "betweenness, closeness, radiality and degree", there were 3 genes found in the intersection (Rv1636, Rv2623 and Rv1566). In the second category of "betweenness, closeness, stress and degree" only one gene (Rv1636) was found in the intersection, as shown in Figure 6.

**Figure 6.** Network analysis: (**a**) PPI network of the selected ten virulent genes which were involved in significant pathways comprised a total number of 93 nodes and 101 edges. (**b**) Venn plot showing the intersection of degree-based radiality category found 3 genes. (**c**) Venn plot showing the intersection degree-based stress category found 3 genes.
