*4.4. Collection of DGS-Related Targets and CAD-Related Targets*

The compounds' structure obtained by mass spectrometry was input in the SMILES format using the Pubchem (https://pubchem.ncbi.nlm.nih.gov/, accessed on 10 December 2021) database. The compounds were imported into the SwissTargetPrediction (http: //www.swisstargetprediction.ch/, accessed on 10 December 2021) database [47] in SMILES format, and the targets of Homo Sapiens species were selected. The results of the predicted targets were screened with a probability value > 0. Finally, the predicted targets were combined and de-duplicated to build a compound target library. All targets for the disease were obtained in the GeneCards (https://www.genecards.org/, accessed on 10 December 2021) database [48] using the keyword "Coronary Artery Disease" and the targets were filtered according to the Relevance score > 20.
