*4.5. Protein–Protein Interaction (PPI) Network*

The intersecting targets were obtained by combining the DGS target library with the CAD target library using the online Venn Analysis tool (http://bioinformatics.psb.ugent. be/webtools/Venn/, accessed on 10 December 2021). All intersecting targets were imported into the String database to obtain protein interaction network data for the intersecting targets. The obtained protein data network was imported into Cytoscape 3.9.1 for PPI visualization and topological analysis. MOCODE, a data connectivity-based plug-in for finding dense regions of the protein interaction networks, was employed to uncover the most closely related protein interaction networks in a complex network [49]. The PPI network was further analyzed using the MCODE plugin in Cytoscape 3.9.1 to identify small, closely related networks in the entire interactions, and the targets in the interactions with the highest scores were selected for subsequent enrichment analyses based on the MCODE clustering scores.
