2.9.5. Solvent Accessible Surface Area (SASA)

Solvent accessible surface area (SASA) analysis was performed to investigate protein folding behavior and stability. While studying the plot, no significant changes in SASA values were observed during the simulation time, suggesting a stable complex. The SASA of native protein was found to be 72.4474 nm<sup>2</sup> and the SASA of the protein-*β*-amyrin complex was 70.9425 nm<sup>2</sup> . A slight decrease in the average SASA signified enhanced packing of the protein-ligand complex, which could also be correlated with the Rg (Figure 9d).
