**5. Conclusions**

Within the limitations of this study, using an SG material—thiol-modified hyaluronic acid (x-tHyA)—the following conclusions were obtained:


**Author Contributions:** Conceptualization, M.T. and H.K.; Methodology, M.T.; Validation and investigation, Y.H., M.T., M.H., W.H., T.S. and H.K.; Formal analysis, Y.H., M.T., M.H. and T.S.; Writing original draft preparation, Y.H., M.T. and M.H.; Writing—review and editing, W.H. and T.S.; Supervision and project administration, H.K. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was funded in part by supported by JSPS KAKENHI grant nos. 21K09984 and 21K17070.

**Institutional Review Board Statement:** The animal study protocol was approved by the Institutional Ethics Committee of Iwate Medical University on 16 April 2018 (approval number: 30-001).

**Data Availability Statement:** All data are included in the manuscript.

**Acknowledgments:** We thank Tomohito Hanasaka of Technical Support Center for Life Science Research, Iwate Medical University for assistance on obtaining SEM photo-micrographs and fluorescence bio-images.

**Conflicts of Interest:** The authors declare no conflict of interest.

## **Abbreviations**


