**8. Conclusions**

As summarised in the current review, insights into membrane protein–lipid interactions are increasing rapidly. The development of novel, non-detergent-based membrane mimetic systems and the use of lipid reconstitution approaches such as nanodiscs for mass spectrometry and electron microscopy sample preparation pave the way for a more physiologically relevant understanding of the interactions between membrane proteins and membrane lipids. In addition, it is clear that the ability to probe potential membrane protein–lipid interactions in silico using Molecular Dynamics simulations where the researcher has unparalleled control of the membrane lipid composition provides an excellent means of providing context to experimental findings and forms the basis for further studies. We are just starting to unpick these complex and important molecular relationships and there is much more to do.

**Author Contributions:** Conceptualization, K.R. and B.B.; writing—original draft preparation, K.R. and B.B. writing—review and editing, K.R. and B.B. Both authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by Biotechnology and Biological Sciences Research Council (BBSRC) gran<sup>t</sup> BB/N016467/1 awarded to Bernadette Byrne.

**Acknowledgments:** The authors also wish to thank Nicole Deacon-Smith for help with the figure preparation.

**Conflicts of Interest:** The authors declare no conflict of interest.
