2.2.4. Methyl (E)-2-{2-[(6-chloro-2-phenylpyrimidin-4-yl)oxy]phenyl}-3-methoxyacrylate (**6**)

A mixture of intermediate **4** (1.00 g, 4.80 mmol), fenclorim **5** (2.16 g, 9.60 mmol), and K2CO<sup>3</sup> (1.33 g, 9.60 mmol) was dissolved in dry dimethylformamid (DMF, 50 mL) at 0 ◦C under nitrogen atmosphere. The mixture was then stirred at this temperature for a further 12 h. The mixture was then poured into ice water (100 mL) and extracted with EtOAc (20 mL) twice. The organic extract was evaporated under vacuum and the residue was purified by silica gel column chromatography (1:7 EtOAc /hexane) to afford compound **6** (2.99 g, 79%). Compound **6** was a white solid with the following characteristics: m.p. 121–122 ◦C; <sup>1</sup>H NMR (300 MHz, CDCl3) <sup>δ</sup> [ppm]: 3.54 (s, 3H, OCH3), 3.67 (s, 3H, OCH3), 6.63 (s, 1H, PyH), 7.24–7.26 (m, 2H, ArH), 7.32–7.35 (m, 2H, ArH), 7.39–7.44 (m, 4H, ArH+CH), 8.28–8.32 (m, 2H, ArH); <sup>13</sup>C NMR (75 MHz, CDCl3) δ [ppm]:170.5, 167.4, 165.0, 162.0, 161.0, 150.3, 135.7, 132.7, 131.6, 129.1, 128.7, 128.5, 126.1, 125.9, 122.0, 107.2, 104.5, 61.8, 50.8 HRMS (ESI+) *m*/*z*: 397.0950 ([M+H]+); found: 397.0946.
