*4.2. Thermal Analysis*

NCM exhibit many unique properties, which are often superior to those of coarsegrained materials. Consequently, NCM offer significant potential for use in a variety of pharmaceutical applications. Solidification of nanosuspensions of NCM has been identified as a tool to increase patient acceptance/adherence and long-term stability [79].

Due to a high-volume fraction of grain boundaries, NCM have the intrinsic shortcoming of poor thermal stability that significantly limits their use. To aid in understanding this drawback, thermal stability has become a significant aspect in the field of pharmaceutical NCM research [80]. It is therefore of utmost importance to conduct thermal analyses on NCM to determine their suitability in potential secondary or downstream pharmaceutical applications.
