2.2.5. 6-chloro-N-2-diphenylpyrimidin-4-amine (**7**)

A mixture of fenclorim **5** (1.00 g, 4.44 mmol), phenylamine (0.34 g, 3.70 mmol) and TEA (0.50 g, 4.44 mmol), was dissolved in dry *N*-methylpyrolidin-2-one (NMP, 20 mL) at 120 ◦C under nitrogen atmosphere for 24 h. The mixture was then cooled to room temperature, and a mixture of EtOAc (20 mL) and saturated sodium chloride solution (20 mL) was added. Then, this mixture was stirred for 30 min. The organic layer was separated, dried using anhydrous sodium sulfate, filtered, and concentrated under a vacuum. Next, the residue was purified using silica gel column chromatography (1:6 EtOAc/hexane) to obtain compound **7** (0.90 g, 72%). Compound **7** was a white solid with the following characteristics: m.p. 95-96 ◦C; <sup>1</sup>H NMR (300 MHz, CDCl3) <sup>δ</sup> [ppm]: 6.61 (s, 1H, PyH), 6.92 (s, 1H, NH), 7.21–7.27 (m, 1H, ArH), 7.36–7.50 (m, 7H, ArH), 8.37–8.41 (m, 2H, ArH); <sup>13</sup>C NMR (75 MHz, CDCl3) δ [ppm]: 164.9, 162.1, 160.9, 137.5, 136.5, 131.1, 129.5, 128.4, 128.3, 125.4, 122.6, 100.5; HRMS (ESI+) *m*/*z*: 282.0790 ([M+H]+); found: 282.0793.
