*2.1. Search Strategy*

The study was designed as a systematic review and meta-analysis and was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement [11].

In this systematic review and meta-analysis, we searched PubMed, Cochrane Library, Web of Science, Scopus from the databases' inception to 1 December 2021 for original, peer-reviewed primary research articles, including observational or interventional studies, that describe the clinical usefulness of tranexamic acid for shoulder arthroplasty. We searched the following terms: "tranexamic acid" OR "TXA" AND "shoulder". Additionally, the reference lists of retrieved articles were also reviewed to identify additional eligible studies. To avoid double data counting, when there were multiple publications from the same trial sample, the one with the largest sample size was included.
