**5. Conclusions**

Tranexamic acid use for shoulder arthroplasty reduces blood volume loss during and after surgery and reduces drain output and hematocrit change.

**Supplementary Materials:** The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/jcm11010048/s1, Table S1: Methodology characteristics among included trials, Figure S1: A summary table of review authors' judgements for each risk of bias item for each randomized study, Figure S2: A plot of the distribution of review authors' judgements across randomized studies for each risk of bias item, Figure S3: A summary table of review authors' judgements for each risk of bias item for each non-randomized study, Figure S4: A plot of the distribution of review authors' judgements across non-randomized studies for each risk of bias item.

**Author Contributions:** Conceptualization, J.P. and L.S.; methodology, J.P.; software, J.P. and L.S.; validation, J.P., L.S. and M.A.-J.; formal analysis, J.P. and L.S.; investigation, J.P., A.S., M.A.-J. and L.S.; resources, L.S.; data curation, J.P. and L.S.; writing—original draft preparation, J.P., M.K., E.M., M.A.-J. and L.S.; writing—review and editing, all authors; visualization, L.S.; supervision, J.P. and L.S.; project administration, J.P. and L.S.; funding acquisition, A.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Acknowledgments:** The study was supported by the ERC Research Net and by the Polish Society of Disaster Medicine.

**Conflicts of Interest:** The authors declare no conflict of interest.
