**5. Conclusions**

While the two-stage exchange arthroplasty can lead to high rates of infection eradication, a third of patients never undergo the second stage of the procedure due to a variety of reasons, including premature mortality, high general morbidity, and low functional demand. Furthermore, shoulder PJI and its treatment is associated with a high risk of mortality, especially in patients with older age and higher CCI. This information needs to be accounted for when counseling frail and elderly patients on the chances and risks before undergoing two-stage exchange arthroplasty for shoulder PJI.

**Author Contributions:** Conceptualization, D.A. and M.W.; methodology, D.A. and N.M.; formal analysis, A.P. and D.K.; data curation, D.A.; writing—original draft preparation, D.A. and M.W.; writing—review and editing, A.P., M.S. and P.M.; supervision, P.M. and M.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Charite Universitätsmedizin ((EA4/040/14, 12 September 2018).

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Data Availability Statement:** Data available on request due to restrictions, e.g., privacy or ethical.

**Conflicts of Interest:** The authors declare no conflict of interest.
