**4. Conclusions**

Electrospun PLA scaffolds are of grea<sup>t</sup> interest in biomedical applications, not only because of their biocompatibility and nanostructure (which resembles the extracellular matrix) but also because they display appropriate degradation times for tissue engineering. In this study, we created a crosslinked PLA network to further extend the degradation time of such scaffolds. We demonstrated that it is possible to create a stable and slow degrading 3D network by activating the sol-gel process during electrospinning. The presence of a polymer diluent was needed to allow the formation of fibers; the crosslinking degree of the network (as well as the final properties) could be modulated by adjusting the proportion of diluent and the molecular weight of the star polymers in the mixture. In addition, these nanofibrillar materials were not cytotoxic and allowed the proliferation of L929 cell line. Future studies will include the incorporation of bioactive peptides (functionalized with IPTES) into the StarPLA network, using our condensation method to fabricate nanofibrillar structures that are not only stable over long periods, but that also trigger a biological response in cells.

**Author Contributions:** Conceptualization, C.P.; validation, C.P. and X.G.; formal analysis, A.B.; investigation, K.B.; writing—original draft preparation, K.B.; writing—review and editing, C.P., X.G. and C.Y.L.-V.; supervision, C.P.; All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was partially funded by the ministry of higher education of Algeria (N◦004Bis/PG./France/2019/2020).

**Data Availability Statement:** The data presented in this study are available on request from the corresponding author.

**Acknowledgments:** We thank Cartigen platform for the access to the SEM equipment.

**Conflicts of Interest:** The authors declare no conflict of interest.

**Sample Availability:** All samples are available from the authors.
