**5. Conclusions**

Over time the polymer changed its morphology, indicating biocompatible degradation. The kinetics of PLA biodegradation revealed herein reinforce PLA's potential for clinical use and may contribute to future research efforts to enable its use in the biomedical industry, including equine medicine.

**Supplementary Materials:** The following are available online, Figure S1: Physiological variables of a horse submitted to the implantation of six poly(lactic acid) (PLA) samples. (A) Heart rate (HR), (B) respiratory rate (RR) and (C) rectal temperature (RT). Figure S2: Plasma fibrinogen concentration (mg/dL) of a horse submitted to the implantation of six polymers of poly(lactic acid) (PLA).

**Author Contributions:** Conceptualization, G.C.F., J.R.G.C., G.C., P.A.C., M.A.C.; methodology, G.C.F., J.R.G.C., G.C., M.L.A., C.H.S., P.P.D., M.A.C., P.A.C., F.J.Z.; formal analysis, J.R.G.C., G.C., M.L.A., C.H.S., T.O.L., P.P.D.; investigation, G.C.F., J.R.G.C., P.P.D.; data curation, G.C.F., J.R.G.C., G.C., M.L.A., C.H.S., P.P.D.; writing—original draft preparation, J.R.G.C., C.H.S., P.P.D.; writing—review and editing, G.C.F., G.C., T.O.L.; supervision, G.C.F., M.A.C., P.A.C., F.J.Z.; project administration, G.C.F., J.R.G.C.; funding acquisition, G.C.F., J.R.G.C. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by The São Paulo Research Foundation–FAPESP, gran<sup>t</sup> number 2017/10959-4, 2015/26738-1, 2018/13685-5, and 2019/16779-3 and the National Council for Scientific and Technological Development (CNPq, process no. 132700/2017-4). Additionally, this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

**Institutional Review Board Statement:** The study was conducted according to the the Ethical Principles in Animal Experimentation adopted by the Brazilian College of Animal Experimentation and was approved and supervised by the Ethics Committee on Animal Use of the CEUA–FCAV/Universidade Estadual Paulista (UNESP) under protocol n◦ 006548/17.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** The raw/processed data required to reproduce these findings are available from the authors upon request.

**Acknowledgments:** We thank Áureo Evangelista Santana and the Clinical Pathology Laboratory of the Veterinary Hospital (FCAV/UNESP) for their excellent technical assistance. The authors are also grateful to Claudia Fiorillo and to The Electron Microscopy Laboratory (FCAV/UNESP) facility for their technical support. Also, we thank the Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) for their technical assistance. We also thank the Graduate Course Program in Veterinary Medicine (FCAV/UNESP), the Graduate Course Program in Animal Science (FCAV/UNESP) and the Department of Animal Morphology and Physiology (FCAV/UNESP) for the academic support.

**Conflicts of Interest:** The authors declare no conflict of interest.
