*Article* **The Influence of Lead-Related Venous Obstruction on the Complexity and Outcomes of Transvenous Lead Extraction**

**Marek Czajkowski <sup>1</sup> , Wojciech Jache´c <sup>2</sup> , Anna Polewczyk 3,4,\* , Jarosław Kosior <sup>5</sup> , Dorota Nowosielecka <sup>6</sup> , Łukasz Tułecki <sup>7</sup> , Paweł Stefa ´nczyk <sup>6</sup> and Andrzej Kutarski <sup>8</sup>**


**Abstract:** Background: Little is known about lead-related venous stenosis/occlusion (LRVSO), and the influence of LRVSO on the complexity and outcomes of transvenous lead extraction (TLE) is debated in the literature. Methods: We performed a retrospective analysis of venograms from 2909 patients who underwent TLE between 2008 and 2021 at a high-volume center. Results: Advanced LRVSO was more common in elderly men with a high Charlson comorbidity index. Procedure duration, extraction of superfluous leads, occurrence of any technical difficulty, lead-to-lead binding, fracture of the lead being extracted, need to use alternative approach and lasso catheters or metal sheaths were found to be associated with LRVSO. The presence of LRVSO had no impact on the number of major complications including TLE-related tricuspid valve damage. The achievement of complete procedural or clinical success did not depend on the presence of LRVSO. Long-term mortality, in contrast to periprocedural and short-term mortality, was significantly worse in the groups with LRSVO. Conclusions: LRVSO can be considered as an additional TLE-related risk factor. The effect of LRVSO on major complications including periprocedural mortality and on short-term mortality has not been established. However, LRVSO has been associated with poor longterm survival.

**Keywords:** lead-related venous obstruction; transvenous lead extraction; lead extraction complications; lead extraction complexity

## **1. Background**

Permanent cardiac pacing remains the leading treatment for patients with various rhythm disorders, conduction disturbances and ventricular arrhythmias. In recent years, we have also observed an increase in the implantation of more complex devices used in the prevention of sudden cardiac death and in the treatment of severe heart failure. In spite of technological progress over the last decade, conventional pacemakers, implantable cardioverter-defibrillators and cardiac resynchronization therapy (PM/ICD/CRT) devices still have endocardial leads. However, after the beginning of the endocardial pacing era only

**Citation:** Czajkowski, M.; Jache´c, W.; Polewczyk, A.; Kosior, J.; Nowosielecka, D.; Tułecki, Ł.; Stefa ´nczyk, P.; Kutarski, A. The Influence of Lead-Related Venous Obstruction on the Complexity and Outcomes of Transvenous Lead Extraction. *Int. J. Environ. Res. Public Health* **2021**, *18*, 9634. https://doi.org/10.3390/ ijerph18189634

Academic Editor: Paul B. Tchounwou

Received: 3 August 2021 Accepted: 9 September 2021 Published: 13 September 2021

**Publisher's Note:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

**Copyright:** © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

a few studies have investigated lead-related venous stenosis/occlusion (LRVSO) [1–20]. Various lead-related problems (infectious and non-infectious) are an inherent component of permanent endocardial pacing, and transvenous lead extraction (TLE) is considered an essential technique in lead management strategy [21–24]. TLE is a complex procedure that sometimes may lead to fatal complications such as venous or cardiac injury. Carrying out the procedure is often associated with technical problems and requires additional approaches and tools [22–25]. There are numerous reports on the estimation of the real risk of the TLE [26–29] but none of them considered LRVSO as a predictor of procedure difficulties. Among twenty reports on LRVSO [1–20], only three papers analyzed the occurrence of LRVSO before TLE [2,6,14], and only two considered the influence of LRVSO on procedure complexity providing at the same time conflicting results. Among 20 reports on LRVSO only two studies were carried out in populations over 200 patients [1,2], 10 in 100–150 participants [3–12] and the remaining eight studies in populations consisting of 30–89 patients [13–20]. In this study, a total of 2909 TLE procedures were preceded by venography and LRVSO was documented in 2138 venograms. Ipsilateral venography before TLE is an integral part of the procedure (in the absence of contraindications for contrast intake).

#### *Goal of the Study*

The aim of this study was to determine the incidence of varying degrees of LRVSO and to examine the influence of LRVSO on procedure difficulty, complexity, major complications related to TLE, procedure effectiveness as well as mid- and long-term mortality after TLE.

#### **2. Methods**

#### *2.1. Study Population*

A post-hoc analysis of clinical data from 2909 patients undergoing transvenous lead extraction (TLE) between June 2008 and March 2021 at a single high-volume center was performed. All information regarding the patients and the procedures were entered into the computer database on a current basis. Patients with medical contraindications for venography (contrast intake) were excluded from the study.

Table 1 summarizes the most important information regarding the study population.

**Table 1.** Characteristics of the study group.


**Table 1.** *Cont*.


AF—atrial fibrillation, CRT-D: implantable cardioverter-defibrillator with resynchronization function, ICD implantable cardioverter-defibrillator, ICD-D—dual chamber implantable cardioverter-defibrillator, ICD-V single chamber implantable cardioverter-defibrillator, IHD—ischemic heart disease, LDTD—lead-dependent tricuspid dysfunction, LVEF—left ventricular ejection fraction, MI—myocardial infarction, MRI—magnetic resonance imaging, SVC—superior vena cava, TLE—transvenous lead extraction.

The current study uses data from a high-volume center that performs more than 200 TLE per year.

The percentage of serious complications is relatively higher compared to other reports, however, in the presented center, the most difficult procedures in the country are performed.

The first line tools used in study center are conventional mechanical sheaths, powered rotational mechanical sheaths and other instruments are second-line tools. Excimer laser sheaths are not used.

#### *2.2. Venography*

Preoperative venography was performed in 2909 patients submitted for transvenous lead extraction between June 2008 and March 2021 at our high-volume center. A peripheral intravenous catheter was placed in the peripheral arm vein on the side (or both sides of the chest) to be examined. All patients received an injection of 20–40 mL high-quality contrast medium (350 mg iodine/mL) Iomeron 350 into the peripheral arm vein on the side of endocardial lead implantation. Venous blood flow in the upper arm, neck and chest was recorded by cine-angiography. All images were acquired in the anteroposterior view. The venograms were obtained in a single plane (anterior–posterior) and stored on CD-ROM discs. An experienced cardiologist and experienced (trained by an interventional radiologist) cardiac surgeon reviewed the venograms, and venous patency was graded on a five-degree scale from normal flow to complete occlusion. All venograms were obtained in the same manner. Venographic analysis: at baseline, the narrowest and widest points of the target vessel for lead placement were identified by visual inspection to obtain minimum and maximum venous diameters, and measurements from two to three individually calibrated frames were averaged to determine the final status of the vein as no stenosis, mild stenosis (<50% narrowing), moderate stenosis (50–80% narrowing), severe stenosis (≥80% narrowing) and complete occlusion of the axillary (AxV), subclavian (ScV), innominate (brachiocephalic) (AnV) veins and superior vena cava (SVC). In spite of contrast injection in the arm vein on the side of the endocardial lead, regional collateral blood vessels and venous collateral blood flow in the neck enabled evaluation of the

brachiocephalic vein on the opposite side of the chest. What is the significance of this classification of vessel narrowing in clinical practice? LVRSO was graded according to our own, arbitrarily estimated, criteria, which rely to the remaining effective vein lumen necessary for different electrodes/catheters safe passage.

Mild narrowing: possible insertion of a new/additional lead using standard introducers, central venous catheters, permanent catheters for hemodialysis and there is a chance that the arteriovenous (AV) fistula will work properly.

Moderate narrowing: probable insertion of a new lead but hydrophilic guide wires and longer introducers are necessary, possible insertion of central venous catheters (troubles possible), possible insertion of permanent catheters for hemodialysis and there is a small chance that the AV fistula will work properly.

Severe narrowing: impossible insertion of a new lead, hydrophilic guide wires and longer introducers might be helpful, insertion of central venous catheters may be risky, chances to pass a catheter for hemodialysis without venoplasty are very small and there is no chance that the AV fistula will work properly.

Complete occlusion: no chance to pass a hydrophilic guide wire; only lead extraction and regaining venous access enables the insertion of a new lead.

Reuse of occluded veins and technical aspects of lead extraction/replacement depend not only on maximal venous narrowing but also on the length of the narrowing (the number of the affected vessels, too).

#### *2.3. Lead Extraction Procedure*

Lead extraction procedures were defined according to the most recent guidelines on management of lead-related complications (HRS 2017 and EHRA 2018) [21–23]. Indications for TLE and type of periprocedural complications were defined according to the 2017 HRS Expert Consensus Statement on Cardiovascular Implantable Electronic Device Lead Management and Extraction [22].

All procedures were performed using non-powered mechanical systems such as polypropylene Byrd dilator sheaths (Cook® Medical, Leechburg, PA, USA), mainly via the implant vein. If technical difficulties arose, alternative venous approaches and/or additional tools such as Evolution (Cook® Medical, Leechburg, PA, USA), TightRail (Spectranetix, Colorado Springs, CO, USA), lassos, basket catheters were used. Excimer laser sheaths were not used.

All extraction procedures were performed following different organizational models spanning 25 years of experience. In the initial era of lead extraction, the procedures were performed in the electrophysiology laboratory using intravenous analgesia/sedation; then the recommended safety precautions were observed to perform more complex and risky procedures in the operating theater, and finally in the hybrid room under general anesthesia. The core extraction team has consisted of the same very experienced TLE operator and a dedicated cardiac surgeon with an experienced echocardiographist over the last six years.

#### *2.4. TEE Monitoring during TLE*

TTE, pre- and postoperative TEE were mandatory (excluding contraindications) from the very beginning. Continuous transesophageal echocardiographic (TEE) monitoring has been an important standard tool over the last six years [30–32]. TEE in our series was performed using Philips iE33 or GE Vivid S 70 machines equipped with X7-2t Live 3D or 6VT-D probes. All recordings were archived and consisted of pre-procedural examination, navigation of lead removal and post-procedural evaluation of the efficacy of the procedure with an assessment of possible complications [30–32]. The intra-procedural phase of TEE monitoring allowed visualization of pulling on the cardiac walls and invagination of the right ventricle during lead removal, followed by a drop in systolic blood pressure in response to this maneuver. Continuous monitoring made it possible to clarify the cause of blood pressure fall during TLE [30–32].

#### *2.5. Statistical Analysis*

The Shapiro–Wilk test showed that most continuous variables were normally distributed. For uniformity, all continuous variables are presented as the mean ± standard deviation. The categorical variables are presented as number and percentage. In the first step the Kruskal–Wallis ANOVA test was used to determine whether there were statistically significant differences between groups. Next, the variables achieving *p* < 0.1 were compared using the nonparametric Chi<sup>2</sup> test with Yates correction (dichotomous data) or the unpaired Mann–Whitney U test (continuous data), as appropriate. Comparisons were made between Groups 1 and 2 vs. Groups 4 and 5. A *p*-value less than 0.05 was considered as statistically significant. In order to assess the effect of LRVSO on mortality, Kaplan–Meier survival curves were plotted, the course of which was assessed using the log rank test. Statistical analysis was performed with Statistica version 13.3 (TIBCO Software Inc., Palo Alto, CA, USA).

## *2.6. Approval of the Bioethics Committee*

All patients gave their informed written consent to undergo TLE and use anonymous data from their medical records, approved by the Bioethics Committee at the Regional Chamber of Physicians in Lublin No. 288/2018/KB/VII. The study was carried out in accordance with the ethical standards of the 1964 Declaration of Helsinki.

#### **3. Results**

#### *Patient Groups*

For the purposes of analysis, the study population was divided into five groups according to venogram results, namely Group 1—no stenosis (499 patients), 2—mild stenosis (574 pts), 3—moderate stenosis (605 pts), 4—severe stenosis (581 pts) and 5—total occlusion (650 pts). Only maximal venous narrowing was considered as a criterion in patient selection.

Tables 2–4 summarize specific patient-, system- and procedure-related risk factors for procedure complexity, efficacy, complications and long-term mortality after TLE.

Analysis of the clinical factors demonstrated that lead-related stenosis/occlusion correlated with patient age during TLE, male gender and Charlson comorbidity index. Other patient-related risk factors for major complications, i.e., indications for CIED implantation, functional NYHA class III and IV, decreased LVEF, renal failure and previous sternotomy were not related to LRVSO (Table 2).

Analysis of CIED systems and history of pacing showed that venous stenosis or leadrelated (LR) total venous occlusion were more frequent in CRT-D recipients. Patients with ICD (VVI, DDD) were less likely, albeit insignificantly to have total venous occlusion.

Patients with redundant loops of the lead before TLE, leads with proximal end in the coronary sinus vein (CSV) and a higher number of CIED-related procedures before lead extraction were more likely to have severe venous stenosis or total occlusion.

Patients with severe venous stenosis or LR total venous occlusion had more risk factors for major complications (MC) and higher procedure complexity estimated with the SAFeTY TLE calculator [26]. These patients also had multiple leads to be removed (including three or more leads), they were more likely to require venous approach on both sides of the chest, extraction of leads with redundant loops in the heart, extraction of abandoned lead (s) and extraction of lead (s) with long or very long implant duration (Table 2).



**Table 2.** Patient-, system- and procedure-related risk factors for procedure complexity and major complications.



cardioverter-defibrillator, IHD—ischemic heart disease, LVEF—left ventricular ejection fraction, MI—myocardial infarction, NYHA—New York Heart Association functional class, TLE—transvenous lead extraction.



**Table 3.** TLE complexity.



**Table 3.** *Cont*.

ICD—implantable cardioverter-defibrillator, TLE—transvenous lead extraction.



**Table 4.** TLE efficacy and complications, and long-term mortality after TLE.



**Table 4.** *Cont*.

Analysis of TLE complexity and degree of LRVSO showed that procedure duration (sheath-to-sheath), extraction of non-functional superfluous leads, occurrence of any technical problem during TLE, lead-to-lead binding, lead fracture during extraction, need to change venous approach, coincidence of three or more technical problems and necessity of using metal sheaths and lasso catheters/snares were associated with the presence of LRVSO (Table 3).

The occurrence of any major complication, urgent rescue cardiac surgery, partial radiographic success (remained tip or <4 cm lead fragment), damage to chordae tendineae, other forms of TLE-related TV dysfunction/damage, complete clinical success and complete procedural success as well as procedure-related death (intra-, post-procedural) did not show any relationship with LRVSO, similar to mortality in the first day, first month and first year after TLE. In contrast, mortality at more than one-year follow-up was significantly higher among patients with severe venous stenosis and complete venous occlusion (Table 4). *Int. J. Environ. Res. Public Health* **2021**, *18*, x FOR PEER REVIEW 9 of 13

Analysis of mortality using the Kaplan–Meier curve confirmed the relationship between LRVSO and long-term survival after TLE (Figure 1).

**Figure 1.** Probability of survival of patients undergoing TLE depending on the degree of LRVSO. **Figure 1.** Probability of survival of patients undergoing TLE depending on the degree of LRVSO.

#### **4. Discussion 4. Discussion**

Venous obstruction is a well-known complication after implantation of a permanent transvenous pacemaker. The incidence of venous obstruction reaches 30–45% with complete occlusion rates of 12% on average and 1–3% for symptomatic occlusion [1–20]. In the current study, severe venous obstruction was identified in 19.94% (40.77% if moderate occlusion was included) whereas complete occlusion in 22.34% of patients. The higher Venous obstruction is a well-known complication after implantation of a permanent transvenous pacemaker. The incidence of venous obstruction reaches 30–45% with complete occlusion rates of 12% on average and 1–3% for symptomatic occlusion [1–20]. In the current study, severe venous obstruction was identified in 19.94% (40.77% if moderate occlusion was included) whereas complete occlusion in 22.34% of patients. The higher

incidence rate of total occlusion in the present study may be a result of long implant duration: cumulative dwell time of the extracted leads was 15.31 ± 12,925 years. Closer eval-

various clinical factors to the occurrence of venous complications [4–6], others show no association between LRVSO and the clinical condition of the patient [7,11]. Analysis of the system/procedure-related factors in the present study demonstrated that the number of extracted leads, lead extraction on the left side or both sides of the chest, extraction of the lead with redundant loop in the heart, extraction of abandoned leads, extraction of leads with long implant duration and a higher risk of MC estimated using the SAFeTY TLE calculator [26] were related to the presence of severe venous stenosis or total venous occlusion. LRVSO was also more common in patients with CRT, having leads with their proximal end in the CVS and a higher number of CIED-related procedures before lead extraction. A similar relationship, especially between the number of extracted leads/long

implant duration and LRVSO has been shown in previous reports [5,11].

incidence rate of total occlusion in the present study may be a result of long implant duration: cumulative dwell time of the extracted leads was 15.31 ± 12,925 years. Closer evaluation of the clinical factors showed that LVRSO was more common in elderly males with a higher Charlson comorbidity index. Several investigators confirm the contribution of various clinical factors to the occurrence of venous complications [4–6], others show no association between LRVSO and the clinical condition of the patient [7,11]. Analysis of the system/procedure-related factors in the present study demonstrated that the number of extracted leads, lead extraction on the left side or both sides of the chest, extraction of the lead with redundant loop in the heart, extraction of abandoned leads, extraction of leads with long implant duration and a higher risk of MC estimated using the SAFeTY TLE calculator [26] were related to the presence of severe venous stenosis or total venous occlusion. LRVSO was also more common in patients with CRT, having leads with their proximal end in the CVS and a higher number of CIED-related procedures before lead extraction. A similar relationship, especially between the number of extracted leads/long implant duration and LRVSO has been shown in previous reports [5,11].

Out of 20 reports, only four described LRVSO diagnosed just before the TLE procedure [2,6,13,14], and only two assessed the influence of LRVSO on the complexity of TLE [2,6]. The last two studies provide contradicting results. Li et al. in a study of 202 patients concluded that the presence of LRVSO made it more difficult to extract the leads, requiring advanced tools and more time [2]. In contrast, Boczar et al. in a group of 133 pts demonstrated that LRVSO did not influence the effectiveness, safety, and the use of additional tools during TLE procedures [6]. In the present study, the indicators of procedural difficulty and complexity such as procedure duration, extraction of superfluous leads, occurrence of any technical problem, lead-to-lead binding, fracture of the extracted lead, need to change venous approach, coincidence of three or more so-called technical problems and need to use metal sheaths or lasso catheters were related to the presence of LRVSO. The occurrence of any major complication was insignificantly higher in groups with LRVSO as compared to groups without significant stenosis: 2.754 and 2.461% vs. 1.603% and 1.742%, respectively. The need to perform urgent rescue cardiac surgery, partial radiographic success and damage to chordae tendinae during TLE were not significantly associated with the degree of LRVSO. The occurrence of TLE-related TV damage, achievement of complete clinical success and complete procedural success as well as procedure-related death (intra-, post-procedural) were unrelated to LRVSO, similar to mortality in the first day, first month and first year after TLE. This study, however demonstrated a link between TLE difficulty/complexity and the degree of LRVSO, which may be a reflection of implant duration and the total number of extracted leads. Thus, the real problem is only with implantation of new lead (s) because of lead dysfunction or necessity of upgrading the CIED system.

The pathophysiology of LRVSO is not well understood. It is likely that lead-related endothelial trauma incites an inflammatory response of the vessel wall with subsequent thrombosis and scarring. Early (days, weeks) LRVSO seems to be a result of thrombosis which can be treated with low-molecular heparin [16–20]. The role of thrombosis in delayed (months) or late (years) LRVSO is less clear. The inflammatory response of the vessel wall probably induces the formation of scar tissue similar to lead adhesion to the vessel and heart structures, observed on the extracted leads and during TEE [33]. The process of natural maturation makes lead-related fibrotic scar harder and harder leading to its mineralization and calcification. It is well-known that scar tissue in the SVC and in the heart makes lead dissection more difficult [34]. However, so far, nobody has considered scar tissue causing LRVSO and scar tissue around the leads detected during TEE/ICS as the same phenomenon. Looking at narrowing or occlusion of implant veins from this viewpoint we can explain the relationship between LRVSO and TLE complexity, difficulty and complications. Lead dissection in scarred veins is more effort-consuming and sometimes requires stronger pulling on the lead to be extracted. It can also explain the mechanism of TV damage during TLE (fortunately rare). It seems to confirm the concept of simultaneous lead traction from

above and below during dissection; it can protect both the SVC wall and the TV [35]. Our results seem to confirm the significance of routine venography before TLE and considering LRVSO as still another risk factor for TLE complexity and major complications.

In the present study, worse long-term survival was demonstrated in patients with a higher degree of LRVSO. The reason for the worse survival rate in this group is not clear and is probably related to other factors as well (possibly a higher Charlson index).

#### **5. Study Limitations**

Our study has several limitations worth noting. Routine venography before TLE was performed in all patients except those with contraindications, mainly renal failure. For this reason, an interesting patient subpopulation had been excluded from the study. The database was prospectively integrated, but analysis was performed retrospectively. For the purposes of this study, the population of patients was divided into groups according to maximal venous narrowing without taking into account the site of narrowing/occlusion and the length of venous stenosis/occlusion. Therefore, the present analysis of venograms includes maximal venous narrowing but not the volume of the phenomenon (the number of vessels affected). The classification of patients we used in the study not only enabled comparison of our results with the findings of other investigators, but also maximal venous narrowing was considered a practical marker for predicting the usefulness of veins for implantation of a new lead/catheter.

#### **6. Conclusions**

The occurrence of significant venous stenosis/occlusion in patients undergoing TLE is related to some clinical factors (age, male gender, high Charlson comorbidity index) and numerous procedure-related factors, especially long implant duration, extraction of leads with redundant loop in the heart, extraction of abandoned leads, presence of leads with proximal end in the coronary sinus vein and a higher number of CIED-related procedures before lead extraction. LRVSO can be considered as an additional risk factor for TLE complexity. Further research is required to provide evidence for the relationship between scar tissue density encapsulating the leads visible in TEE and the degree of LRVSO. Leadrelated venous stenosis/occlusion has no influence on mortality at one-year follow-up, but the presence of severe forms of LRVSO is associated with worse prognosis of patients undergoing TLE at more than one-year follow-up.

**Author Contributions:** Writing—original draft preparation, M.C.; methodology and statistical study, W.J.; investigation and corresponding author, A.P.; data curation, J.K., D.N., Ł.T. and P.S.; writingreview and editing, A.K. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the of Bioethics Committee at the Regional Medical Chamber in Lublin protocol number 288/2018/KB/VII.

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Data Availability Statement:** Readers can access the data supporting the conclusions of the study at www.usuwanieelektrod.pl (accessed on 11 September 2021).

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **Abbreviations**



#### **References**


## *Case Report* **Successful Catheter Ablation of the "R on T" Ventricular Fibrillation**

**Zofia Lasocka, Alicja D ˛abrowska-Kugacka \* , Ewa Lewicka, Aleksandra Lizewska-Springer and Tomasz Kr ˙ ólak**

Department of Cardiology and Electrotherapy, Medical University of Gda ´nsk, 80-211 Gdansk, Poland; zofia.lasocka@gumed.edu.pl (Z.L.); ewa.lewicka@gumed.edu.pl (E.L.); aleksandra.lizewska-springer@gumed.edu.pl (A.L.-S.); tomasz.krolak@gumed.edu.pl (T.K.)

**\*** Correspondence: alicja.dabrowska-kugacka@gumed.edu.pl

**Abstract:** In patients with idiopathic ventricular fibrillation (VF), recurrent implantable cardioverterdefibrillator (ICD) shocks might increase mortality risk and reduce patients' quality of life. Catheter ablation of triggering ectopic beats is considered to be an effective method. We present a patient with recurrent VF, caused by the "R on T" premature ventricular complexes. In the presented case radiofrequency catheter ablation efficiently eliminated arrhythmia trigger, which was possible to detect thanks to the intracardiac electrocardiograms (ECG's) stored in the ICD.

**Keywords:** ventricular fibrillation; R on T phenomenon; catheter ablation; mapping

## **1. Introduction**

Idiopathic ventricular fibrillation (VF) occurs in healthy individuals without structural heart disease. Although most sudden cardiac deaths (SCDs) are associated with identifiable causes, idiopathic VF accounts for 5% to 10% of out-of-hospital cardiac arrest [1]. In such patients, the gold standard treatment for either primary or secondary prevention of VF is the insertion of an implantable cardioverter-defibrillator (ICD). The goal is however to determine the mechanism of spontaneous arrhythmia. Intracardiac electrocardiograms (IECGs) stored in ICD provide information about cardiac rhythm preceding arrhythmic events and may be helpful to reveal their mechanism [2].

Mapping during VF reveals few sources triggering the arrhythmia. In patients with idiopathic VF, premature ventricular complexes (PVCs) triggers usually arise either from right ventricular outflow tract region or from the Purkinje network [3]. The Purkinje network fibers originate from the bundle branches, whose function is to distribute the depolarization wavefront to the left and right ventricles, allowing for their simultaneous activation. However, Purkinje cells have shown to have abnormal automaticity and triggered activity, what may play a significant role in the initiation of VF in patients with both structural heart disease and normal hearts [4–6].

As recurrent ICD shocks might increase mortality risk and reduce patients' quality of life, anti-arrhythmic drugs are recommended [7]. According to the Optimal Pharmacological Therapy in Cardioverter Defibrillator Patients (OPTIC) trial, which included patients with secondary prevention ICD indication, amiodarone compared to b-blocker reduced the risk of both appropriate and inappropriate shocks [8]. However, if pharmacological treatment is not successful or the patient experiences drug-related side effects, radiofrequency (RF) ablation can be considered if VF is triggered by PVCs [3–5].

#### **2. Case Report**

We present the history of a 62-year-old male with recurrent VF triggered by the "R on T" ventricular premature beats. In 2006, he underwent cardiac arrest and was diagnosed with idiopathic VF, as no apparent structural cardiac disease or other cause of the arrhythmia was found. Twelve-lead surface electrocardiogram (ECG) showed sinus rhythm, with normal QRS complexes and repolarization, while 24-hour ECG monitoring revealed multiple monomorphic PVCs (<1000) and no other abnormalities. In the echocardiographic

#### **Citation:** Lasocka, Z.;

D ˛abrowska-Kugacka, A.; Lewicka, E.; Lizewska-Springer, A.; Królak, T. ˙ Successful Catheter Ablation of the "R on T" Ventricular Fibrillation. *Int. J. Environ. Res. Public Health* **2021**, *18*, 9587. https://doi.org/10.3390/ ijerph18189587

Academic Editor: Salah A. Mohamed

Received: 14 July 2021 Accepted: 6 September 2021 Published: 11 September 2021

**Publisher's Note:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

**Copyright:** © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

examination good left ventricular ejection fraction (LVEF) of 70%, without any segmental hypo/akinesis was found. A coronary angiogram revealed no narrowing in the coronary arteries. Cardiac magnetic resonance was not performed in 2006, as it was not widely available at that time. The patient was implanted with a single-chamber ICD for secondary prevention of sudden cardiac death. At hospital discharge, anti-arrhythmic treatment with amiodarone 200 mg and metoprolol 50 mg daily was prescribed. endocardial activation site and maximal pace-mapping correlation (93% according to PaSo module) was found in the antero-lateral right ventricular free wall (Figure 2C). RF ablation current was delivered at 30 W of power-controlled mode with a temperature of 43 °C for 30–60 sec.

*Int. J. Environ. Res. Public Health* **2021**, *18*, x 3 of 6

Webster, Irvine, CA, USA) three types of right ventricular endocardial maps were created: the bipolar map during sinus rhythm, the correlation map of pace-mapping (using PaSo module), the activation map during clinical PVCs. The bipolar map revealed no abnormalities. The earliest

Within the next year, amiodarone was withheld due to thyreotoxicosis. Thyroid function was normalized, metoprolol dose was increased to 175 mg daily, but VF episodes occurred about one to two times per year and were terminated by ICD shock. As presented on Figure 1, the 12-lead ECG revealed singular PVCs with morphology of right ventricular free wall origin. The initial ICD was replaced in 2016 due to battery replacement indications. Stored IECGs revealed VF episodes initiated by the "R on T" PVCs and terminated spontaneously, by anti-tachycardia pacing (ATP) or high-voltage shocks (Figure 2A,B). To reduce the number of painful ICD interventions, as pharmacological treatment was not efficient, the patient was referred for elective electrophysiological study (EPS) and RF ablation of ectopic beats. Pre-ablation 24-hour ECG monitoring showed sinus rhythm, 1629 single monomorphic PVCs with around 300 qualified as "R on T". Clinical spontaneous PVCs were eliminated, but pacing delivered from right ventricular lead of ICD occasionally induced single PVCs with slightly different morphology compared to the clinical PVCs. In the follow-up, until June 2021 the patient remained asymptomatic and without episodes of VF or ventricular tachycardia in the ICD control. The patient's quality of life increased significantly. 24-hours ECG monitoring revealed sinus rhythm and only eight PVCs. Metoprolol was gradually reduced to 50 mg daily.

**Figure 1.** 12-lead electrocardiogram (ECG) with premature ventricular complex (PVC) originating from the right ventricular free wall. **Figure 1.** 12-lead electrocardiogram (ECG) with premature ventricular complex (PVC) originating from the right ventricular free wall.

**Figure 2.** Ventricular fibrillation (VF) episodes resulting in implantable cardioverter-defibrilator (ICD) interventions, from the time of ICD reimplantation to the decision to perform radiofrequency ablation (A); ICD intracardiac recording showing the premature ventricular complex (PVC) triggering VF. VF initiating PVC is similar to the previously registered PVC (arrows) (B); Right anterior oblique 30° view of right ventricular endocardial activation map obtained during spontaneous PVCs: the earliest activation site was located in the antero-lateral right ventricular free wall (red area) (C). ATP – antitachycardia pacing, IEGM – intracardiac electrocardiogram, RR – consecutive R waves on the IEGM **Figure 2.** Ventricular fibrillation (VF) episodes resulting in implantable cardioverter-defibrilator (ICD) interventions, from the time of ICD reimplantation to the decision to perform radiofrequency ablation (**A**); ICD intracardiac recording showing the premature ventricular complex (PVC) triggering VF. VF initiating PVC is similar to the previously registered PVC (arrows) (**B**); Right anterior oblique 30◦ view of right ventricular endocardial activation map obtained during spontaneous PVCs: the earliest activation site was located in the antero-lateral right ventricular free wall (red area) (**C**). ATP—antitachycardia pacing, IEGM—intracardiac electrocardiogram, RR—consecutive R waves on the IEGM.

> **3. Discussion**  Our case demonstrates the efficacy of RF ablation in a patient with recurrent idiopathic VF, and ineffective antiarrhythmic treatment. IECGs from the ICD provided information about the mechanism of the arrhythmic episodes, which in the presented case was the "R on T" phenomenon. Indeed, electrocardiogram stored in the ICD devices is comparable to continuous Holter monitoring. Information, such as the day and time of the episode, the preceding heart rate, the influence of preceding premature beats and their morphology can be obtained from Ablation catheter (Thermocool Smarttouch SF, Biosense Webster, Johnson and Johnson Medical, Ltd., Irvine, CA, USA) was introduced to the right ventricle through a femoral approach under fluoroscopic guidance. Using CARTO 3 mapping system (version 7.1, Biosense Webster, Irvine, CA, USA) three types of right ventricular endocardial mapswere created: the bipolar map during sinus rhythm, the correlation map of pace-mapping (using PaSo module), the activation map during clinical PVCs. The bipolar map revealed no abnormalities. The earliest endocardial activation site and maximal pace-mapping correlation (93% according to PaSo module) was found in the antero-lateral right ventricular free wall (Figure 2C). RF ablation current was delivered at 30 W of power-controlled modewith a temperature of 43 ◦C for 30–60 sec. Clinical spontaneous PVCs were eliminated, but pacing delivered from right ventricular lead of ICD occasionally induced single PVCs with slightly different morphology compared to the clinical PVCs.

> the IECG records analysis. In other words, it enables the physician to identify the arrhythmia trigger, underlying recurrent VF or ventricular tachycardia, and consequently, to apply the most appropriate treatment [2]. In the follow-up, until June 2021 the patient remained asymptomatic and without episodes of VF or ventricular tachycardia in the ICD control. The patient's quality of life increased significantly. 24-hours ECG monitoring revealed sinus rhythm and only eightPVCs. Metoprolol was gradually reduced to 50 mg daily.

#### In up to 70% of patients after ICD implantation antiarrhythmic agents **3. Discussion**

need to be initiated, in order to treat atrial tachyarrhythmias, terminate ventricular arrhythmias and decrease the frequency of ICD shocks. Class III antiarrhythmic drugs, such as amiodarone and sotalol, are widely considered to be effective in preventing ICD shocks [9]. However, potential cardiac and drug-related adverse effects of antiarrhythmics should be taken into consideration, as apart from ICD/drug interactions, these are the most frequent causes of drug discontinuation. In our case amiodarone was withheld due to thyreotoxicosis. The concomitant Our case demonstrates the efficacy of RF ablation in a patient with recurrent idiopathic VF, and ineffective antiarrhythmic treatment. IECGs from the ICD provided information about the mechanism of the arrhythmic episodes, which in the presented case was the "R on T" phenomenon. Indeed, electrocardiogram stored in the ICD devices is comparable to continuous Holter monitoring. Information, such as the day and time of the episode, the preceding heart rate, the influence of preceding premature beats and their morphology can be obtained from the IECG records analysis. In other words, it enables the physician to identify the arrhythmia trigger, underlying recurrent VF or ventricular tachycardia, and consequently, to apply the most appropriate treatment [2].

pharmacological therapy turned out insufficient to prevent recurrent ventricular tachyarrhythmias. In up to 70% of patients after ICD implantation antiarrhythmic agents need to be initiated, in order to treat atrial tachyarrhythmias, terminate ventricular arrhythmias and

decrease the frequency of ICD shocks. Class III antiarrhythmic drugs, such as amiodarone and sotalol, are widely considered to be effective in preventing ICD shocks [9]. However, potential cardiac and drug-related adverse effects of antiarrhythmics should be taken into consideration, as apart from ICD/drug interactions, these are the most frequent causes of drug discontinuation. In our case amiodarone was withheld due to thyreotoxicosis. The concomitant pharmacological therapy turned out insufficient to prevent recurrent ventricular tachyarrhythmias.

To reduce the number of ICD shocks, catheter ablation of the triggering PVCs was recommended. Pace-mapping allowed identification of the PVCs' origin. According to recent reports, PVCs triggering VF arise either from the myocardium (right or left ventricular outflow tract) or from the distal Purkinje network [4]. In the study on 27 patients with recurrent episodes of idiopathic VF, PVCs originated from the Purkinje conducting system in 23 patients, while from right ventricular outflow tract only in 4 study counterparts [3]. There is a growing body of evidence that the Purkinje network, consisting of a single branch on the right and 2 larger branches on the left heart side, plays a significant role in both the initiation and maintenance of VF. It has been proved that RF ablation of arrhythmia triggers effectively prevent VF recurrence in a high-risk population [5,6]. Decreasing the incidence of ventricular arrhythmias catheter ablation may reduce defibrillation requirement and improve the patient's quality of life.

#### **4. Conclusions**

In conclusion, implantation of ICD is the gold standard treatment for both primary and secondary prevention of SCD. The primary goal is to identify the mechanism underlying the spontaneous arrhythmia. In the presented case, RF ablation efficiently eliminated the arrhythmia trigger, which was identified thanks to the stored intracardiac electrograms. RF ablation is considered an effective method of arrhythmia termination, in case of antiarrhythmic drugs intolerance or inappropriate ICD shocks. Although the long-term results are very encouraging, ablation of triggering PVCs for VF does not replace ICD implantation.

**Author Contributions:** Conceptualization, A.D.-K.; formal analysis, Z.L., A.D.-K., E.L., and T.K.; investigation, Z.L., A.D.-K., and E.L.; writing—original draft preparation, Z.L.; writing—review and editing, A.D.-K., E.L., A.L.-S., and T.K.; supervision, A.D.-K., E.L. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Independent Bioethics Committee for Scientific Research at Medical University of Gdansk–NKBBN/660/2021.

**Informed Consent Statement:** Written informed consent has been obtained from the patient to publish this paper.

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**

