**About the Editors**

#### **Istvan Simon**

Istvan Simon was born in Budapest, Hungary, in 1947. He graduated as a physicist and ´ habilitated in biology and physics. He is a member of the Hungarian academy of Sciences, and currently a professor emeritus at the Institute of Enzymology of the Research Centre for Natural Sciences, where he has been since 1969. He turned his attention to computational analysis at Cornell University, where he spent several years in the group of Harold A. Scheraga. He continued his career in this field in Hungary, and pioneered computational protein structure research at the end of the 1970s. He has published 9 books chapters and 135 papers. The publication have been cited over 12,000 times, and he has twice been listed among the highly cited researchers according to the Web of Science. Together with his research group, he has provided 16 databases and prediction servers on the World Wide Web. These include the prediction of "stabilization centers", i.e., residue pairs that are responsible for keeping a proteins's structure intact, the prediction of disulfide-forming cysteines (CYSREDOX), and a number of top-cited transmembrane prediction algorithms (DAS, HMMTOP, and PDBTM). Recently, his group has uncovered the statistical thermodynamics forming the background of protein disorder, and provided the corresponding prediction server, IUPRED, followed by the prediction of functional regions of disordered proteins (ANCHOR). The strength of these methods is the groundbreaking discovery of principles underlying protein structure organization.

#### **Csaba Magyar**

Csaba Magyar was born in Budapest, Hungary, in 1972. He graduated as a physicist, his interest turned to computational chemistry already during his university years. He received the Ph.D. degree in 2001, and currently is a senior research fellow at the Institute of Enzymology of the Research Centre for Natural Sciences in Hungary. In the first year of his career he studied the structural background of thermal stability of proteins by utilizing homology modeling and molecular dynamics simulations. Protein stability remained in the focus of his research interest as a postdoc, he was working on the concept of stabilization centers in proteins, developed the concept of stabilizing residues, and set up the SRide web server. Gradually his interest turned to the investigation of protein–protein and protein–ligand complexes. In recent years, he has worked on a special subclass of disordered proteins, called Mutual Synergistic Folding proteins. He was awarded with the Youth Prize of the Hungarian Academy of Sciences, and the Bolyai Janos Research Fellowship. ´
