*Commentary* **Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione**

**Alessio Bocedi 1, Giada Cattani 1, Giorgia Gambardella 1, Linda Schulte 2, Harald Schwalbe <sup>2</sup> and Giorgio Ricci 1,\***


**Abstract:** Glutathione has long been suspected to be the primary low molecular weight compound present in all cells promoting the oxidative protein folding, but twenty years ago it was found "not guilty". Now, new surprising evidence repeats its request to be the "smoking gun" which reopens the criminal trial revealing the crucial involvement of this tripeptide.

**Keywords:** oxidative folding; glutathionylation; nitrosylation; cysteine reactivity; ribosomal exit tunnel; transient complex; glutathione
