*Review* **Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications**

**Mariarosaria Valente 1,2,\*, Marta Dentoni <sup>1</sup> , Fabrizio Bellizzi <sup>1</sup> , Fedra Kuris <sup>1</sup> and Gian Luigi Gigli 1,2,\***


**Abstract:** Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases.

**Keywords:** specialized pro-resolving mediators; resolvins; maresins; annexins; lipoxins; protectins; glial cells; neuroinflammation; neurodegeneration; cerebrovascular disorders; multiple sclerosis; dementia
