*4.8. Statistical Analyses*

The differences were subjected to one-way analysis of variance (ANOVA) followed by Bonferroni's test; *p* values < 0.05 versus vehicle were considered significant.

**Author Contributions:** Conceptualization and supervision, K.M. and K.I.; formal analysis, K.M., M.Y., S.N., and T.K. (Takayuki Kondo); investigation, K.M., M.Y., S.N., and T.K. (Takayuki Kondo); resources, T.K. (Toshiaki Kume) and H.I.; writing—original draft preparation, K.M.; writing—review and editing, K.I.; project administration, K.I. All authors have read and agreed to the published version of the manuscript.

**Acknowledgments:** We are thankful to Masahiro Maeda in IBL for providing ELISA kits. This study was in part supported by the Japanese government (Monbukagakusho: MEXT), grant number 17H06405 to K.I. and K.M. for Scientific Research on Innovative Areas 'Frontier Research on Chemical Communications', a grant for Core Center for iPS Cell Research of Research Center Network for Realization of Regenerative Medicine from AMED to H.I., and the JSPS KAKENHI, grant number 18K18452 to T.Ko. and H.I., grant number 17K16121 to T.Ko.

**Conflicts of Interest:** The authors declare no conflict of interest.
