*Article* **Mosquito-Textile Physics: A Mathematical Roadmap to Insecticide-Free, Bite-Proof Clothing for Everyday Life**

**Kun Luan 1,2, Andre J. West 3,\*, Marian G. McCord 1, Emiel A. DenHartog 2, Quan Shi 2, Isa Bettermann 4, Jiayin Li 3, Nicholas V. Travanty 5, Robert D. Mitchell III 5, Grayson L. Cave 5, John B. Strider 5, Yongxin Wang 2, Florian Neumann 4, Tobias Beck 4, Charles S. Apperson 5,6 and R. Michael Roe 5,6,\***


**Simple Summary:** Mosquitoes can bite across clothing and transmit disease. This is prevented with pesticides applied to clothing. We developed non-insecticidal cloth and garments that provided 100% protection, were comfortable and look-like and feel-like regular clothing.

**Abstract:** Garments treated with chemical insecticides are commonly used to prevent mosquito bites. Resistance to insecticides, however, is threatening the efficacy of this technology, and people are increasingly concerned about the potential health impacts of wearing insecticide-treated clothing. Here, we report a mathematical model for fabric barriers that resist bites from *Aedes aegypti* mosquitoes based on textile physical structure and no insecticides. The model was derived from mosquito morphometrics and analysis of mosquito biting behavior. Woven filter fabrics, precision polypropylene plates, and knitted fabrics were used for model validation. Then, based on the model predictions, prototype knitted textiles and garments were developed that prevented mosquito biting, and comfort testing showed the garments to possess superior thermophysiological properties. Our fabrics provided a three-times greater bite resistance than the insecticide-treated cloth. Our predictive model can be used to develop additional textiles in the future for garments that are highly bite resistant to mosquitoes.

**Keywords:** mosquito; bite-proof garment; model; textile; non-insecticidal; physical barrier
