**Contents**

Reprinted from: *Foods* **2022**, *11*, 992,


doi:10.3390/foods11070992

...................

 **117**


### *Editorial* **The Potential of Food By-Products: Bioprocessing, Bioactive Compounds Extraction and Functional Ingredients Utilization**

**Michela Verni 1,\* and Federico Casanova 2**


Achieving sustainability in the agro-food sector can only be possible with the valorization of food industry waste and side streams, products with an extremely high intrinsic value but often discarded because they are unfit for further processing that meets consumer expectations. Apart from their use as feed, a more practical solution responding to the modern vision of a circular economy must be sought. In this framework, this Special Issue aimed at covering the most recent advances in the valorization of food by-products (of both animal and plant origin), from extraction to bioprocessing, including their application in a variety of food-related industries throughout the entire food supply chain.

Several processes can guarantee that the potential of food industry by-products is fully unleashed, generating high-value ingredients while ensuring nutritional quality. For example, ultrasound technology was successfully used to extract phenolic acids, flavonoids, anthocyanins, and carotenoids from *Morus alba* leaves [1], pomegranate peels and seeds [2], guaraná by-products [3], and horchata, a Spanish beverage obtained from pressing tiger nut by-products [4]. Such side streams, rich in phenolic compounds, are often studied for their beneficial properties on human health, particularly their antioxidant properties determined in vitro [1,2,4–6]. The extraction of olive pomace phenolic compounds, followed by their purification using macroporous absorbing resins was also explored by Zhao et al. [5], confirming the grea<sup>t</sup> potential as natural antioxidants, preservatives, and antimicrobials in clean-label foods.

Enzymatic treatments, alone or ultrasound-assisted, are among the processes employed to valorize food industry waste and by-products [7–9]. Ultrasound-assisted enzymatic treatment was often used to extract soluble and insoluble dietary fibers from orange peel [7] and olive pomace [8]. The renowned physiological effects of dietary fibers are varied and often inversely correlated to obesity, type two diabetes, cancer, and cardiovascular disease. Lignocellulosic-based adsorbents from sugarcane bagasse, cornstalk piths, and corn cob were also found to improve the physicochemical properties and quality of fried oils [10]; nevertheless, beyond the technological properties of dietary fibers, their cholesterol adsorption capacity [7] and antioxidant and prebiotic activity [8] sugges<sup>t</sup> that the application of such by-products in functional foods should be recommended. Indeed, L-arabinose, a bio-active compound derived from the processing of many fibrous materials, was studied by Pol et al. [11], who concluded that its addition to sugary drinks used for a clinical trial, despite the large quantities of starch and fat, significantly lowered postprandial glycemic and insulinemic responses in healthy subjects.

Although the sole extraction and characterization of the compounds of interest is the most preferred option, as in the above-reported cases, as well as for *Aloe vera* anthraquinones [12] or sesame oil asarin [13], the use of the whole discarded biomass is the valorization alternative that can prevent the further generation of by-products and should be preferred in terms of sustainability of the overall upcycling process. This option

**Citation:** Verni, M.; Casanova, F. The Potential of Food By-Products: Bioprocessing, Bioactive Compounds Extraction and Functional Ingredients Utilization. *Foods* **2022**, *11*, 4092. https://doi.org/10.3390/ foods11244092

Received: 12 December 2022 Accepted: 16 December 2022 Published: 17 December 2022

**Publisher's Note:** MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

**Copyright:** © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

was chosen by Najjar et al. [14] for the valorization of date seed flour, incorporating it in composite cookies and thus leading to a high amount of total polyphenolic content, with flavonoids showing high in vitro antioxidant activity.

Two review articles were also collected in this Special Issue. One of them overviewed the development of starch-based films as environmentally friendly packaging alternatives which could also be prepared by adding antioxidant or anti-bacterial substances, thus extending food shelf-life, and reducing food waste [15]. The other review focused on the interaction of dairy and plant-based proteins, more specifically, the application of pulsed electric field technology to enhance the functional properties of food proteins [16]. Indeed, the colloidal and acid gelling properties of mixed suspensions of pea and milk proteins [17], and the foaming properties of pea protein isolates and fish skin gelatin [18] were the subject of other studies. In addition, Guan et al. [19] exploited the use of aquatic collagen, obtained from by-products of fish processing, concluding that its higher thermal stability compared to that of terrestrial sources of collagen provides promising applications in food, cosmetics, and biomedical fields.

The research papers published in this Special Issue represent some of the novel strategies at our disposal to valorize waste and by-products generated by the food industry. However, much more support is needed in the future, from academia, industry, government, and consumers, to make sure more sustainable approaches can be put in place to minimize or counteract this issue.

**Author Contributions:** M.V. and F.C. contributed equally to the proposal, editorial work of this Special Issue, and to the writing of the editorial. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Conflicts of Interest:** The authors declare no conflict of interest.
