*4.1. Study Design*

This study was a parallel, double-blind, randomized controlled 12-week clinical trial conducted from summer 2017 to winter 2018 at the Institute of Nutrition and Functional Foods in Quebec City (QC, Canada). The study was in accordance with the Declaration of Helsinki and was approved by the Université Laval's health-science research ethics committee. Participants were given a detailed written informed consent form to read and sign prior to their participation in the study. This trial was registered at clinicaltrials.gov as NCT03075943.
