*3.1. Weight Loss*

With respect to anthropometric parameters, our results showed that the improvement in body weight and composition induced by consumption of 500 mg per day brown seaweed extract rich in polyphenols with dietary modifications aimed at moderate weight loss was not greater than that provoked by dietary modifications alone. The lack of additional weight loss is consistent with recent data from Derosa et al. [27], who reported no effect of 6-month administration of food supplement containing *Ascophyllum nodosum* and *Fucus vesiculosus* extract and chromium picolinate on body weight and BMI in dysglycemic subjects. On the other hand, De Martin and co-authors [26] reported a significant decrease in waist circumference in overweight and obese subjects after 6 months of treatment with the same nutraceutical combination that had been administered in the study by Derosa et al. [27]. In light of these studies, it is possible that a reducing effect of brown seaweed extract on body weight was masked by the effect of the low-calorie diet in the present study. It is also to be considered that the absence of additional weight loss could be attributed to the dysglycemic status of our subjects or to the absence of chromium picolinate in the supplement.
