**3. Discussion**

The study investigated the effect of brown seaweed (*Ascophyllum nodosum* and *Fucus vesiculosus*) extract (InSea2®) rich in polyphenols combined with a moderate weight loss on glycemic and metabolic control among prediabetic overweight/obese subjects over 12 months. In this study, we advised both groups to follow a moderate energy-restricted balanced diet. Therefore, body weight, waist circumferences, and total fat mass decreased significantly in both groups. The main findings in this study indicate that daily consumption of 500 mg of brown seaweed extract had no effect on body weight and blood glucose, our primary outcomes, but had a modest beneficial impact on insulin secretion through the reduction of late C-peptide secretion during 2 h OGTT, heart rate and on the inhibition of the rise of IL-6 concentration in plasma compared with placebo in the context of moderate weight loss.
