*2.5. Effect of OPs on Hepatic Injury in Cd-Exposed Mice*

The organ weight coefficient is commonly used to evaluate the toxic effect [24]. The liver weight coefficient of the mice in the Cd-exposed group was significantly higher than that of the mice in the control group (*p* < 0.01). The OPs markedly lowered the liver coefficients in Cd-exposed mice (*p* < 0.01). Histopathological sections of the liver stained with H&E are shown in Figure 3B. Compared with the control group, the mice in the Cd group showed obvious pathological changes in liver tissue, including apoptotic bodies, hemorrhage, lymphocyte accumulation, and inflammatory cell infiltration around the central vein. In the OPs and EDTA-treated groups, liver tissue retained its normal appearance and had fewer apoptotic bodies. OPs showed a protective effect on liver tissue against Cd.

**Figure 3.** Effects of OPs on liver coefficient and hepatic injury in Cd-exposed mice. (**A**) Liver coefficient = liver weight(g)/mouse weight(g); (**B**) Histopathology with H&E staining (200×) of the liver in mice after treatment for 7 days; CV: Central veins; Arrow: lymphocyte accumulation in the parenchyma; asterisk (\*): hemorrhage. Bar = 100 μm. The data were expressed as mean ± SEM, *n* = 6 in each group. Compared with the control group, \*\* *p* < 0.01; compared with the Cd group, ## *p* < 0.01.
