*Review* **<sup>67</sup>Cu Production Capabilities: A Mini Review**

**Liliana Mou <sup>1</sup> , Petra Martini <sup>2</sup> , Gaia Pupillo <sup>1</sup> , Izabela Cieszykowska <sup>3</sup> , Cathy S. Cutler <sup>4</sup> and Renata Mikołajczak 3,\***


**Abstract:** Is the <sup>67</sup>Cu production worldwide feasible for expanding preclinical and clinical studies? How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for personalized therapies? This review looks at the different production routes, including the acceleratorand reactor-based ones, providing a comprehensive overview of the actual <sup>67</sup>Cu supply, with brief insight into its use in non-clinical and clinical studies. In addition to the most often explored nuclear reactions, this work focuses on the <sup>67</sup>Cu separation and purification techniques, as well as the target material recovery procedures that are mandatory for the economic sustainability of the production cycle. The quality aspects, such as radiochemical, chemical, and radionuclidic purity, with particular attention to the coproduction of the counterpart <sup>64</sup>Cu, are also taken into account, with detailed comparisons among the different production routes. Future possibilities related to new infrastructures are included in this work, as well as new developments on the radiopharmaceuticals aspects.

**Keywords:** Cu-67; copper radionuclides production; radiopharmaceuticals; theranostics
