**4. Conclusions**

We report a simplified and efficient automated purification method for [89Zr]zirconium oxalate with high radionuclidic purity using the commercially available TRASIS miniAiO automation module. This method showed reproducible results for the production of [89Zr]zirconium oxalate. Additionally, the automated process with disposable cassettes provides sterile [89Zr]zirconium oxalate and documentation of the manufacturing process that can be used to fulfil cGMP requirements. This automated process can also be adopted for [89Zr]Cl<sup>2</sup> production. With adequate shielding, the module ensures safe user operation and environmental radiation protection. This study strongly reinforces the utility of commercially available automated modules for the production of cGMP grade <sup>89</sup>Zr.

**Author Contributions:** V.G. and J.C. performed the experiments and wrote the manuscript. H.F. designed experiments, supervised the study and edited the manuscript. C.R.G. edited the manuscript and helped obtain grant for the study. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was funded by a grant from Sylvia Fedoruk Center (grant # J2016-0036).

**Acknowledgments:** The authors like to acknowledge the contribution and support from the staffs of the Saskatchewan Centre for Cyclotron Science (SCCS). Authors also like to acknowledge the contributions from the staffs of Advanced Cyclotron Systems Inc. (ACSI).

**Conflicts of Interest:** All authors declare they have no conflicts of interest.
