*4.16. Ethical Approval*

The protocol described and all the animal procedures were approved by the General Directorate of Veterinary Services (Athens, Attica Prefecture, Greece) and by the Bioethical Committee of BIOEMTECH Laboratories (Permit number: EL 25 BIOexp 045) on the basis of the European Directive 2010/63/EU on the protection of animals used for experimental purposes.
