*p*-value by non-parametric Mann–Whitney test. All values are median (with interquartile range –IQR unless stated otherwise). CT-INTEM (*p* = 0.008), MCF-INTEM (*p* = 0.001), and MCF-EXTEM (*p* = 0.001) all significantly differed with time. AUC = area under curve; CT = clotting time; MCF = maximum clot firmness; PFA = platelet function analyzer.

#### *3.1. Cardiovascular Results*

MAP over time are summarized in Figure 2. The median time to induce hemorrhage to achieve a MAP ≤ 40 mmHg was within 4 min (interquartile range [IQR] 2.75–8.75) in the treatment group and 5 (3–7.75) minutes in the control group which were not statistically different (*p* = 0.939). A significantly larger amount of blood was, however, withdrawn to achieve and maintain this MAP target for 60 min for the dogs treated with resveratrol compared to control (median 63.8 vs. 54.9 mL respectively, *p* = 0.041), with a slightly lower MAP at end of one-hour of hemorrhage in the resveratrol group (33 vs. 39 mmHg respectively, *p* = 0.041). Arterial and venous pH were also significantly lower in the treatment group versus control group at end of one-hour of hemorrhage (arterial 7.24 vs. 7.35, *p* = 0.011; venous 7.23 vs. 7.32, *p* = 0.047 respectively). The other blood gas and hemodynamic parameters between the two groups were not significantly different (Tables 4 and 5). Time for the MAP to return to ≥ 60 mmHg following cessation of induced bleeding and initiation of Gelofusine® fluid resuscitation was not different between the two groups (R group: median 17, IQR 12.5–25 vs. C group: 14, IQR 11.3–17.3; *p* = 0.571). No additional fluid administration was required in any dog in order to maintain MAP > 60 mmHg during the subsequent three-hour reperfusion period. There were also no significant differences in the arterial and venous blood gases including OER between the two groups during the experiment.

**Figure 2.** Changes in mean arterial pressure (MAP) over time in anesthetized greyhounds subjected in a pressure-targeted hemorrhage model. Values are median and interquartile range. (**A**) Control group (*n* = 6). (**B**) Resveratrol pretreated group (*n* = 6).

**Table 4.** Arterial and venous blood gas parameters during the experiment (*n* = 12).


#### **Table 4.** *Cont.*

