*3.2. Safety Evaluation*

Four complaints of symptoms were received during the study period, including fatigue, constipation, headache, and stiffness in the shoulder, although the symptoms were present before study participation and, although the cause could not be identified, the symptoms were mild and thus were judged by the investigator to be unproblematic. No abnormal values were found for vital signs such as blood pressure and pulse, nor in the blood test results. Subjects' blood pressure, pulse rate, and blood test results are summarized in Supplementary Tables S1 and S2. Although some items significantly differed between weeks, most average values remained within the range of the reference value. No adverse events or other associated issues were observed.
