*4.3. Response 1 (Y1): Effect of Investigated Independent Variables on PS*

The PS of APG-PEGylated CNPs was influenced by the selected independent variables; the average PS of multiple batches of formulations ranged from 120.52 nm to 354.2 nm, as shown in the Table 2. The following polynomial equation describes the mathematical relationship between independent variables and PS for APG-PEGylated CNPs. The coded equation assists in identifying the correlation of factors and PS (Equation (2)).
