*2.10. Solubility Test*

Solubility studies were performed using the Crystal16 equipment (Technobis Crystallization Systems, Alkmaar, The Netherlands) in water. The equipment comprised four individually controlled reactors, each with a working volume of 1 mL, allowing the measurement of cloud and clear points based on the turbidity of 16 aliquots of 1 mL of solution in parallel and automatically. Each solution was heated at 0.3 ◦C/min from 20 to 90 ◦C with a magnetic stirring rate of 700 rpm, held at this temperature for 10 min and then cooled to 20 ◦C at 0.3 ◦C/min. The dissolution temperature for each compound was measured using different amounts of solid, and the solubility data of the pure components were fitted to a quadratic equation [29] using the CrystalClear software (Technobis Crystallization Systems, Alkmaar, The Netherlands).
