*2.1. Preparation of Bilastine Crystal Forms*

The organic solvents used were all of analytical quality. The screen included evaporations, cooling crystallizations at different rates, antisolvent precipitations, antisolvent diffusions and slurries (see details in the Supplementary Materials). The experimental solid form screening resulted in six solid forms (three anhydrates and three chloroform solvates) as confirmed by PXRD and thermal analysis.
