*2.1. Liquid-Assisted Grinding (LAG)*

For the LAG [10,12,13] experiments, different molar ratios of about 100 mg scale and 100 μL of dichloromethane (DCM) were added to each tube. Stoichiometric mixtures of lidocaine **(lid)** and **(lidhc)** with the coformers resorcinol **(res)**, hydroquinone **(hq)**, and pyrogallol **(pyr)** were gently ground for 30 min at 25 Hz in a Retsch MM400 ball mill (Haan, Germany). A multiple milling homemade accessory allowing for grinding 12 samples at once was used, placing 12 2 mL Eppendorf tubes with three corundum 1 mm balls each.

Three different stoichiometries (1:1, 2:1, 1:2) were screened for each system. The powder materials obtained were analysed by PXRD, FTIR, and DSC/TGA to determine the formation of cocrystals. Cocrystals exhibited distinct PXRD patterns and melting points compared to the starting materials.
