*Article* **Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide**

**Basanta Saikia \*, Andreas Seidel-Morgenstern and Heike Lorenz**

Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; seidel@mpi-magdeburg.mpg.de (A.S.-M.); lorenz@mpi-magdeburg.mpg.de (H.L.)

**\*** Correspondence: saikia@mpi-magdeburg.mpg.de

**Abstract:** Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD). The eutectic mixtures i.e., AMG-CAF (1:0.4, molar ratio), AMG-NIC (1:1.9, molar ratio) and AMG-ZMD (1:1.4, molar ratio) demonstrate significant melting point depressions ranging from 99.2 to 127.2 ◦C compared to the melting point of the drug AMG (151 ◦C) and also show moderately higher aqueous solubilities than that of the AMG. The results presented include the determination of the binary melt phase diagrams and accompanying analytical characterization via X-ray powder diffraction, FT-IR spectroscopy and scanning electron microscopy.

**Keywords:** aminoglutethimide; eutectic mixture; solubility; melt phase diagram
