*2.2. Stability Experiments*

In order to investigate the stability with respect to dissociation, a suspension of about 100 mg scale was made with 0.5–1 mL of 0.9% NaCl solution. The suspensions were subjected to magnetic stirring at ambient conditions for 24 h without drying completely, keeping a slurry all the time. Aliquots of the slurry were taken, gently ground, and analysed by PXRD to determine if the cocrystal was dissociated into its components, suffered any transformation, or remained stable in the cocrystal form.

To study the influence of temperature and humidity on the stability of the new phases, these materials were left in a temperature/humidity-controlled chamber with a temperature of 40 ◦C and 75% relative humidity for 2 months, taking sample aliquots during this time to be analysed by PXRD to evaluate the stability of the crystalline phase. All the samples remained stable as a cocrystal form after 2 months.
