**4. Conclusions**

In this study, a new ARI-ADI salt and its acetone hemisolvate were successfully synthesized and fully characterized by various methods, along with a reported ARI-SAL salt. Their crystal structures revealed that the proton transferring occurred from a carboxylic group of CCF to the N2 atoms of the piperazine region from the ARI. Structural analysis showed that the ARI-SAL salt was arranged helically by two helices propagated along the b axis, while the ARI-ADI salt acetone hemisolvate presented a typical layer stacking with the help of weak C-H··· Cl and C-H··· π hydrogen bonds. The reactivity of ARI and CCF was predicted by MEPS and matched well with their hydrogen bond schemes. Hirshfeld surface analysis was also used to clarify the intermolecular interactions. Furthermore, the ARI-ADI salt had a significant advantage over the ARI and ARI-SAL salt in terms of equilibrium solubility and IDR. This study provided a valuable insight into the formation of multicomponent pharmaceutical salts and presented potential alternative formulations of ARI.

**Author Contributions:** Conceptualization, D.Y. and J.T.; tests and data interpretation, Q.Z., Z.T., Y.W. and Y.Z.; writing—original draft preparation, Q.Z.; review and editing, Q.Z., Y.L. and G.G. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Data Availability Statement:** The data used to support the findings of this study are included within the article.

**Conflicts of Interest:** The authors declare no conflict of interest.
