*2.5. Solubility Determination*

The gravimetric method was used to determine the solubility of AMG and its binary eutectic mixtures in water at room temperature (25 ◦C). An excess amount of solid eutectic mixture was added to 4 mL water, and the suspension was stirred at 300 rpm at 25 ± 1 ◦C for 72 h to reach equilibrium. Then it was allowed to settle before liquid phase sampling. The saturated solutions of respective eutectic mixtures were filtered using a 0.45 μm syringe filter and transported in a 5 mL vial. The weight of the full vial with the solution was recorded immediately. The vials were kept in a fume hood for evaporation of the water. Solids were obtained after ~3–4 days. They are further placed in a desiccator for 1 day. All measurements were carried out in duplicate. The solubility of pure AMG (mg/mL) in water was calculated from the product of the mass of the dried material (solubility of eutectic mixture) and the respective AMG content in the dried eutectic mixture (in weight fraction).
