**3. Results and Discussion**

In literature, it was pointed out [1,10] that organic eutectic formation happens when the molecular interaction among identical molecules is comparably stronger than the interaction between different molecules. Till now, there are no exact rules to design eutectics based on the cohesive interactions dominant over the adhesive interaction to produce a eutectic [4,10]. Generally, a cocrystal is expected to be obtained when the possibility of formation of very strong adhesive interactions is high. However, when the cohesive interactions are strong but auxiliary interactions are weak to nil, as long as molecular mismatched shapes are there, then the formation of a eutectic mixture is expected [10]. In the case of AMG, the interactions like imide*···* imide and N−H*···* O hydrogen bond interactions are relatively stronger (Figure 1). However, in the case of multicomponent systems with the coformers CAF, NIC and ZMD, the adhesive interactions are relatively weaker as they are non-isomorphous molecules with a considerable mismatch in size and shape. Moreover, the structural arrangement will have lack a unique lattice arrangement distinct from the individual components and thus retains the cohesive interactions in its eutectic mixtures. Therefore, the X-ray diffraction pattern and spectroscopic signature

peaks of a eutectic mixture does not contain new crystalline arrangement, rather contains the overlapping of diffraction peaks of the individual components.

**Figure 1.** Examples of some probable supramolecular synthons that may be present in AMGeutectic systems.

The Cambridge Structural Database (CSD) search for imide and carboxylic acid interaction only reveals two reported crystal structures with refcodes HUVGAI and UGOHUV, demonstrating the weaker probability of cocrystal formation via the imide*···* carboxylic acid heterosynthon. Similarly, no imide and only one monosubstituted pyridine interaction have been observed from CSD search for the multicomponent crystalline systems of imide functional molecules. There is also no reported structure with imide*···* carboxamide interaction. Furthermore, cocrystal screening by considering the molecular complimentary screening wizard of CSD [24] also reveals no-hit for cocrystals for the selected coformers.
