*2.10. Solubility Studies*

Solubility studies for pure FUR and each new cocrystal were performed using the Crystal16 equipment (Technobis Crystallization Systems, Alkmaar, The Netherlands) in water PBS at pH 7.4. The equipment is comprised of four individually controlled reactors, each with a working volume of 1 mL, allowing the measurement of cloud and clear points based on the turbidity of 16 aliquots of 1 mL of solution in parallel and automatically. Each composition was heated at 0.5 ◦C/min to 90 ◦C with a magnetic stirring rate of 700 rpm, held at this temperature for 10 min and then cooled to 20 ◦C at 0.5 ◦C/min. The temperature of dissolution for each compound was measured using different amounts of solid, and the solubility data of the pure components were fitted to the Van't Hoff equation [28] using the CrystalClear software (Technobis Crystallization Systems, Alkmaar, The Netherlands).
