**Appendix A**

**Table A1.** Definition of terms used in health economic analyses.



**Table A2.** Transition probabilities for the health states in the model.

AE: adverse event; ICU: intensive care unit; SD: standard deviation. \* Transition probabilities were calculated from day 180 relative risk. SDs were calculated on the basis of a 95% confidence interval (Clopper–Pearson confidence interval for a binomial proportion, with https://epitools.ausvet.com.au/ciproportion; accessed on 1 Septemeber 2021).

**Table A3.** Clinical outcomes in patients randomized to the intervention and the control group according to the original report.


Data are number of events (%). Models were adjusted for initial nutritional risk screening score and study center. Continuous values are expressed as means and SDs, categorical/binary values as absolute numbers and percentages. MACE: major cardiovascular events, containing myocardial infarction, stroke, and all-cause mortality.


**Table A4.** Sensitivity analysis results for ICER per life-year.

ICER incremental cost-effectiveness ratio; costs were rounded to the full amount. SF 1 = EUR 0.95.
