*8.2. Resveratrol Conjugated and Grafted Polymers*

Resveratrol exhibits comparable antioxidant activity as quercetin, polyphenols, Vitamin C, and E, phenolic compounds, carotenoids, α-lipoic acid, melatonin, gallic acid, and

N-acetyl cysteine, captopril. However, the material is superior to other antioxidants based on its broad biological activity, including anticancer, anti-inflammatory and chemoprevention properties, and rapid metabolism within the body due to its shortened half-life [104]. The mechanical, biological, and chemical properties can be enhanced through modifications in the synthetic routes. For example, Siddalingappa et al. [104] reported the successful synthesis of Resveratrol-PEG ethers via alkali-mediated etherification. The plasma stability of the moieties was augmented by aggregation behavior and polymer hydrophobicity, and the antioxidant demonstrated ideal antioxidant behavior in mice models. Further customized changes were viable through carbodiimide coupling reaction-mediated surface and chemical modifications with α-methoxy poly (ethylene glycol)-co-polylactide succinyl ester resveratrol, MeO-PEG succinyl ester resveratrol, and α-methoxy-ω-carboxylic acid poly(ethylene glycol) succinylamide resveratrol [104].
