*2.2. Modeling of LRI*

Modeling of relatively "soft" X-ray radiation of LRI was carried out on an LNK-268 (RAP100-10) X-ray unit (Diagnostika-M LLC, Moscow, Russia) with a radiation exposure mode at a dose of 110 Gy with a 0.1 mm aluminum filter, voltage 30 kV, beam current 6.1 mA, dose rate 21.1 Gy/min for 312 s (dose accuracy ± 5%, dose measurement uncertainty ± 6%) according to the proposed earlier method [10–12], leading to a short latency period and chronic skin ulcer in laboratory animals. After irradiation, the animals were seated in individual sterile boxes with an autonomous Smart Flow ventilation system (Tecniplast Group, Buguggiate, Italy), with free access to water and food.
