**6. Conclusions**

MSC-exosomes show potential for repairing radiation damage. Current data reveal that MSC-exosomes have therapeutic potential due to their anti-inflammatory effects and promotion of angiogenesis and epithelial survival, which are crucial biological processes in the remodeling of radiation damage. In addition, the immunomodulatory effects of MSC-exosomes probably enhance their tissue repair function. Overall, MSC-exosomes have good prospects for the treatment of radiation injury and this may inspire future research in this field.

**Author Contributions:** X.P. and S.M. wrote the manuscript. X.P., Y.G. and T.X. proposed and drew the figures. P.C. and L.D. reread and corrected the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study is supported by the National Natural Science Foundation of China (No. 81773353 and No. 81874254); the Jilin Scientific and Technological Development Program (No. 20190201204JC); and the Foundation of Scientific Research Planning Project of the 13th Five-year Plan of Jilin Provincial Department of Education (Grant No. JJKH20201043KJ).

**Conflicts of Interest:** The authors declare no conflict of interest.

#### **References**

