**Table 2.** *Cont.*

a NR: not reported in references.

In conclusion, through this review, we conveyed that (1) the mangrove-associated ecosystem is still an abundant source of bioactive NPs providing leads for drug development, (2) chemical syntheses of several of the mangrove-associated NPs are completed, but more NPs are to be synthesized and more efficient routes are to be developed, and (3) and the biosynthesis of most of the mangrove-associated NPs remain unclear.

**Author Contributions:** All authors equally contributed to the review and their specific contributions to the preparation of this review are as follows: investigation and writing—original draft preparation: M.-J.W.; visualization and writing—review and editing: B.X.; conceptualization, review and editing, funding acquisition: Y.-W.G. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the National Natural Science Foundation of China (No. 81991521) and the SKLDR/SIMM Project (No. SIMM2013ZZ-06).

**Conflicts of Interest:** The authors declare no conflict of interest.
