*3.2. Fungal Material*

The mangrove fungal strain *A. ustus* 094102 was isolated from the rhizosphere soil of the mangrove plant *Bruguiera gymnorrhiza* grown in Wenchang, Hainan Province of China. It was identified according to the morphological characteristics and the ITS sequences [4,5].

## *3.3. Cultivation and Extraction*

The fungus *A. ustus* 094102 was statically cultured at 25 ◦C for 28 days in one hundred 1000 mL conical flasks, each containing 300 mL of the liquid medium that was prepared by dissolving maltose (20 g), mannitol (20 g), glucose (10 g), monosodium glutamate (10 g), yeas<sup>t</sup> extract (3 g), corn steep liquor (1 g), CaCO3 (2 g), KH2PO4 (0.5 g), MgSO4·7H2O (0.3 g), and sea salt (33 g) in 1 L of tap water (pH 7.0). The whole fermentation broth (30 L) was filtered by cheesecloth to separate the mycelia from the filtrate. The mycelia were extracted three times with an 80% volume of aqueous acetone. The acetone solution was concentrated under reduced pressure to give an aqueous solution. The aqueous solution was extracted three times with an equivalent volume of ethyl acetate (EtOAc), while the filtrate was extracted three times with an equivalent volume of EtOAc. All EtOAc extracts were combined and concentrated under vacuum to give 240 g of crude gum.
