**5. Conclusions**

In summary, our current study identified several novel genes as the potential biomarkers or treatment targets for OA, which will benefit both synovium and cartilage. In combination with the excellent works published by worldwide researchers, we hope our work could pave the path for developing the new generation of DMOADs.

**Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/21/17/ 6033/s1. Table S1. The information of the samples included in the current study; Table S2. The list of the identified pathways from the Reactome database; Table S3. The biological processes described in the Uniprot database for the genes with the same expression trends in response to OA; Table S4. The biological processes described in the Uniprot database for the genes with different expression trends in response to OA.

**Author Contributions:** Conceptualization, C.L.; methodology, C.L. and Z.Z.; validation, C.L. and Z.Z.; formal analysis, Z.Z.; writing—original draft preparation, C.L.; writing—review and editing, Z.Z. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest.
