ABT-122

ABT-122 is an IgG1 dual-variable domain immunoglobulin (DVD-Ig) that was engineered to bind to and neutralize human TNF and IL-17A. It is built on an adalimumab backbone by adding IL-17A binding domains [139–141]. Although the dual inhibition of TNF and IL-17A was expected to provide greater effects compared to adalimumab, which targets only TNF, two phase 2 clinical studies have failed to demonstrate the superiority of ABT-122 for the treatment of PsA compared to adalimumab at 12 weeks [141,142].
