*4.7. Statistical Analysis*

All quantified results were expressed as the mean ± SE. Significant differences in the osteonecrosis development rate in the H&E-stained specimens, were determined by Fisher's exact test. Statistical significance in the comparison of %PC of TFAM or ATP5A between the control and each of the experimental groups was analyzed with Dunnett's multiple comparison test. Significance was defined as *p* < 0.05. The statistical analysis was performed using Stat View J-5.0 software (SAS Institute, Cary, USA)

**Author Contributions:** All authors made a significant contribution to the study and are in agreement with the content of the manuscript H.H., T.I., M.S., S.U. and Y.U. conceived and designed the experiments; H.H., T.I., M.S. and S.U. performed the experiments; H.H., T.I., M.S. and S.U. analyzed the data; H.H., T.I., M.S., S.U., Y.U., A.K. and N.K. interpreted the data and drafted the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest.
