*4.9. Statistical Analysis*

Age, sex, PASI score, number of tender or swollen joints, disease duration, treatment regimen, miRNA expression level, number of osteoclasts formation, and resorption area were compared among groups by chi-square, *t*-test, One-way ANOVA, or logistic regression based on the data normality. Receiver-operator characteristic analysis (ROC) and area under the curve (AUC) were used to assess whether expressions of miRNAs in CD14+ monocytes, could distinguish between PsA samples and PsO samples or healthy controls. A *p*-value less than 0.05 was considered statistically significant for all tests.

**Author Contributions:** S.-H.L. designed the study, conducted the experiments, analyzed the results, and wrote the manuscript. C.-H.L. and C.-C.H. contributed to study design, analyzed the results, and critically revised the paper. S.-C.L. contributed to data analysis. J.-C.H., Y.-W.C., Y.-C.Y., J.-F.C., C.-Y.H., T.N., F.-S.W., and M.-Y.Y. contributed to data acquisition. All authors have read and agreed to the published version of the manuscript.

**Funding:** The authors received grants from Ministry of Science and Technology of Taiwan (MOST 105-2628-B-182A-004-MY3 and MOST 108-2314-B-182A-105-MY3) and the Chang-Gung Memorial Foundation (CMRPG8J0411).

**Acknowledgments:** We thank the Genomics & Proteomics Core Laboratory, Department of Medical Research, Kaohsiung Chang-Gung Memorial Hospital for technical support. Kaohsiung, Taiwan.

**Conflicts of Interest:** The authors declare that they have no competing interests.
