*4.9. Statistical Analysis*

All data were presented as mean±SEM. The results were analyzed using one-way ANOVA, and multiple comparisons were conducted by Tukey's HSD using GraphPad Prism (version 5.0). The statistical significance was considered as *p* < 0.05.

**Author Contributions:** Conceptualization, H.-C.C., S.-Y.L., C.-H.C. and C.-Z.W.; methodology, H.-C.C.; software, H.-C.C., S.-C.C., L.-Y.C., Y.-S.L.; validation, Y.-S.L., L.-Y.C., S.-Y.L., M.-L.H., C.-Z.W. and C.-H.C.; formal analysis, H.-C.C., S.-Y.L., T.-L.C., L.K., Y.-H.W., C.-Z.W. and C.-H.C.; investigation, H.-C.C.; data curation, H.-C.C.; writing—original draft preparation, H.-C.C. and S.-Y.L.; writing—review and editing, S.-Y.L., C.-H.C. and C.-Z.W.; project administration, H.-C.C., S.-Y.L., C.-H.C. and C.-Z.W.; funding acquisition, S.-Y.L., C.-H.C. and C.-Z.W. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was supported in part by the Minister of Science and Technology of Taiwan (MOST 109-2314-B-037-026, MOST108-2320-B-037-008 and MOST109-2320-B-037-005), Kaohsiung Medical University Hospital (KMUH105-5M30), Kaohsiung Medical University (KMU-TP105B10 and KMU-DK105009), Kaohsiung Medical University (KMU-TC108A02-1). The funder had no conflicts of interest including in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.

**Acknowledgments:** We appreciate the support from members of our orthopedic research center and Department of Physiology, Regeneration Medicine and Cell Therapy Research Center, Graduate Institute of Medicine, College of Medicine of Kaohsiung Medical University, Kaohsiung City, Taiwan.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
