*4.7. Functional Annotation*

Gene ontology analysis was performed using ToppGene and ToppCluster [44] and enriched gene ontology terms and pathways (*p*-value < 0.01) were identified. Cytoscape (version 3.6.1) was used for ontology and pathway visualization [45].

**Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/21/1/364/s1.

**Author Contributions:** Study design: A.S. and G.G.L.; Data acquisition: A.S., D.K.M., M.E.M., N.D.R.-A., N.R.H., J.L.M., and B.A.C. Data analysis and interpretation: A.S., B.A.C., and G.G.L. A.S. and G.G.L wrote the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** A.S., D.K.M., N.R.H., and G.G.L. were supported by Lawrence Livermore National Laboratory LDRD grants 20-LW-002 and 16-ERD-007. G.G.L. and B.A.C. were supported by DOD PR180268/P1 and NIH R01 AR075013.

**Acknowledgments:** This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
