*4.10. Statistical Analysis*

Data were expressed as mean ± standard deviation. Statistical significance was assessed by the Mann-Whitney U test. All statistical analyses were performed using Stata/SE version 8.0 for Windows (StataCorp, College Station, TX, USA). Two-tailed *P* values less than 0.05 were considered significant. The datasets analyzed during the current study are available from the corresponding author on reasonable request.

**Author Contributions:** H.-C.Y., C.-H.T., K.-Y.H., H.-B.H. and M.-C.L. conceived and designed the study. H.-C.Y. and H.B.H. performed the experiment. C.-H.T., K.-Y.H. and M.-C.L. analyzed and interpreted the data. M.-C.L. wrote the paper. All authors revised the manuscript critically for the important intellectual content. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by grants from the Ministry of Science and Technology (MOST 107-2314-B-303-020-MY3) and Buddhist Tzu Chi Medical Foundation (TCMF-A 108-05(109)), Taiwan.

**Acknowledgments:** We thank Malcolm Koo for his writing assistance and statistical advice.

**Conflicts of Interest:** The authors declare no conflicts of interest.

#### **Abbreviations**


