**5. Strength and Limits**

The present study has several strengths. Not only the relation of FA with ED treatment outcome was explored, a characterization of different phenotypes in ED patients that presents FA was confirmed. In this sense, it is important to consider that the clustering process was performed in the original study for a large set of indicators measured in the baseline (previously to the intervention), which included the ED severity level along with other variables (the comorbid psychopathological status, the personality traits and the diagnostic subtype). In this sense, belonging to a specific cluster provides wide information on the patients' profile in a broad collection of clinical measures. Since this work provides results for the comparison between these empirical profiles, this study can be conceptualized within a person-centred approach, characterized by the analysis of individuals who share multiple particular attributes (contrarily to the classical variable-centred approach, focused on assessing the specific contribution of isolated variables). Additionally, these clusters have specific clinical characteristics, which may inform precision therapies.

Even so, some limitations may be taken into account. The study was only performed in women patients, and the size of the sample was considerably reduced due to the exclusion of patients with obesity only (as the aim of this paper was on ED treatment response). These aspects affect the generalization of the results, and future studies should consider them.
