**2. Materials and Methods**

The purpose of this narrative review is to synthesise a theoretical rationale for the use of ketamine in the treatment of anorexia nervosa, integrating research across multiple disciplines (e.g., investigational research of ketamine for other psychiatric disorders). A literature search in the electronic databases MEDLINE and PubMed was performed until 15 September 2021, focusing on neurobiological models of anorexia nervosa and ketamine use within a psychiatric setting. An analysis of eligible publications using MeSH keywords such as "ketamine", "neuroplasticity", "anorexia nervosa" and "neurobiol" was conducted. Articles published in English were considered, and there were no restrictions on the type of article for inclusion; population-based studies, reviews, systematic reviews, meta-analyses, clinical trials and theoretical papers were included in this narrative review. Reference lists of publications were searched in order to identify additional eligible articles.
