*2.3. Metabolically Healthy Group*

According to their baseline features, patients were classified as: (1) "Metabolically healthy" (**MH**; *n* = 505; 38.8%) if they showed normal blood pressure, lipid profile (low density and high density (LDL-c, HDL-c) lipoproteins and triglycerides), and serum glucose and uric acid levels at diagnosis or (2) "Not metabolically healthy" (**No-MH,** *n* = 795, 61.2%) if one or more of these parameters were impaired. Additionally, patients were classified according to their fasting insulin levels as insulin resistant (**IR**, fasting insulin ≥ 15 μU/mL; *n* = 481; 37%) or **No-IR** (fasting insulin < 15 μU/mL *n* = 819, 63%).

Standardized BMI, blood pressure, fasting lipid profile, glucose, insulin, uric acid levels and HOMA index at baseline were compared between **MH** and **No-MH** patients, also accounting for the presence or absence of **IR**. In addition, the evolution of these features was studied by longitudinally comparing status at baseline and the end of follow-up, considering the eventual role of the background of **IR** at diagnosis.
