**6. Conclusions**

The phenotypic characterization of FA proposed by the original study [18] (considering ED and obesity patients), and the present one (only considering ED patients), present similar clinical characteristics that again defined three clusters from a dysfunctional to functional one. The dysfunctional cluster had the lower rates in full remission, while the functional cluster had the higher proportions of full remission and the lowest of dropouts. Even though the moderate cluster presented the highest rate of dropouts, a higher percentage of participants in this cluster could reach full remission of their symptoms. Even though all participants presented FA symptoms, the differential characteristics of each cluster may be important to defining proper treatment approaches for ED patients with FA. For example, the dysfunctional cluster may benefit from treatments that target aspects of high severity ED symptoms and psychological distress; the moderate cluster may be specifically benefited by a focused treatment for the reduction of FA symptoms; finally, the functional cluster could continue with traditional approaches.

**Author Contributions:** Conceptualization: L.M., A.G.-P., S.J.-M., F.F.-A.; methodology: R.G.; formal analysis: R.G.; investigation: L.M., A.G.-P., I.S., C.V.-A.; resources: S.J.-M., F.F.-A.; data curation: R.G.; writing—original draft preparation: L.M., A.G.-P., S.J.-M., R.G., F.F.-A.; writing—review and editing: L.M., S.J.-M., A.N.G., F.F.-A.; supervision: L.M., S.J.-M., C.D., A.N.G., F.F.-A.; funding acquisition: S.J.-M., F.F.-A. All authors have read and agreed to the published version of the manuscript.

**Funding:** We thank CERCA Programme/Generalitat de Catalunya for institutional support. This manuscript and research was supported by grants from the Ministerio de Economía y Competitividad (PSI2015-68701-R), by the Delegación del Gobierno para el Plan Nacional sobre Drogas (2017I067 and 2019I47), by the Instituto de Salud Carlos III (ISCIII) (FIS PI17/01167 and PI20/132), by the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya by the call "Acción instrumental de programes de recerca orientats en l'ambit de la recerca i la innovaci\_o en salut", and cofounded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. CIBERObn is an initiative of ISCIII.

**Institutional Review Board Statement:** The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of University Hospital of Bellvitge (PR205/17).

**Informed Consent Statement:** Informed consent was obtained from all subjects involved in the study.

**Conflicts of Interest:** F.F.-A. received consultancy honoraria from Novo Nordisk and editorial honoraria as EIC from Wiley. The rest of the authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
