*2.4. Procedure*

The CLAS at Hospital del Mar receives daily requests for interventions with patients who present an SUD concomitantly to their cause of admission. As part of standard procedure, clinical and sociodemographic data are collected in a database and include details of substance use and comorbidities (including serological status of HIV and hepatitis viruses). Patients who met the inclusion criteria were informed and, if they agreed to participate, an independent researcher conducted the study. DDSI was performed first followed by the WHO Well-being Index and the SDS. The total time of the evaluation was a maximum of 25–30 min.

Due to the COVID-19 lockdown (from 10 March 2020 to 22 June 2020) the independent researcher had no face-to-face access to the patients. Basic sociodemographic and clinical data gathered from the CLAS in this period were analysed.

#### *2.5. Analysis of Data*

A descriptive analysis of variables was carried out and possible differences by gender from the interviews were analysed. To do so, the mean, median, standard deviation, range, and frequency were calculated according to the nature of each variable. Kolmogorov– Smirnov normality tests were performed and, consequently, non-parametric tests were used. For the comparison of means between groups the Mann–Whitney and Wilcoxon U tests and Chi-square for categorical variables were employed. All calculations were carried out using the IBM (IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY, USA: IBM Corp.).
