*2.1. Ethics Statement*

All the protocols were carried out in accordance with the recommendations of the Guide for the Care and Use of Laboratory Animals, according to resolution 196/96 of the National Council for Animal Experimentation—COBEA (https://sbcal.org.br/ (accessed on 2 March 2020)). All the procedures used in this study were approved by the Animal Use Ethics Committee of IOC/Fiocruz (L-005/2017). According to the Brazilian Law of Biodiversity, this study was registered at SisGen (AA2236F).
