**5. ROS Production in** *Plasmodium***-Infected Erythrocytes under Antimalarial Treatment**

Oxidative stress is not only an important clinical and pathobiochemical factor but also an effective therapeutic principle in malaria. Indeed, the pharmacological activity of some of the most important antimalarials, such as quinolines, atovaquones, and artemisinin derivatives, is mediated by the high production of ROS, exceeding the oxidative stress management capacities of the parasite [16,93].
