*2.12. Statistical Analysis*

Analyses were performed with GraphPad Prism version 8.0 for Windows (GraphPad Software, San Diego, CA, USA) or IBM SPSS Statistics 22.0 software (IBM Corporation, New York, NY, USA). Asterisks indicate significant differences with the threshold for significance set at *p* ≤ 0.05. Student's t test or two-way ANOVA were used to analyze the statistical significance between the strains. The pairwise comparisons and the number of biological replicates are described in figure legend.

#### **3. Results**
