*2.5. Endpoints*

The co-primary endpoints of this systematic review were the impact of investigational treatments on lung function and symptoms control.

The secondary endpoints were the impact of investigational treatments on blood eosinophil count, FENO, exacerbations and hospitalisations, the use of rescue medications, and QoL.

## *2.6. Strategy for Data Synthesis*

Data from original papers were extracted and reported via qualitative synthesis, and the statistical significance was set at *p* < 0.05.
