*3.2. Cytokines*

Low-dose OmeGo significantly reduced IL-13 by 11%, and high-dose OmeGo drove a 24% reduction in serum IL-13 levels (*p* < 0.01) and a 17% reduction in IL-4 (*p* < 0.05), all compared to cod liver oil. OmeGo did not significantly impact IL-6, IL-17A or CXCL-1 levels. Fevipiprant significantly reduced CXCL-1 (32%, *p* < 0.001), IL-4 (58%, *p* < 0.001), IL-6 (18%, *p* < 0.05) and IL-13 (63%, *p* < 0.001) but not IL-10 or IL-17A. In terms of changes in serum IgE levels, the 12% reduction with OmeGo and the 6% reduction with fevipiprant were non-significant (Figure 5).

**Figure 5.** Mean serum cytokine levels at study end with cod liver oil, two doses OmeGo, or fevipiprant. \*\* denotes *p* < 0.01, \* denotes *p* < 0.05.
