*3.16. Antifungal Triazoles*

Respiratory fungal infections complicate lung diseases and, particularly in severe asthma, up to 70.0% of patients are sensitised to at least one fungal allergen [5,99,100]. In a Phase I RCT [38,39], a single dose of inhaled PC945 5 mg did not induce a change in FEV1 (defined as >15.0% change from baseline, measured 10 min after receiving PCB) in mild asthmatic patients, and no acute bronchospasm was observed.
