*Systematic Review* **Oral Manifestations in Scurvy Pediatric Patients: A Systematic Review and a Case Report**

**Maria Francesca Gicchino 1, Antonio Romano <sup>2</sup> , Speranza Cioffi 1, Fausto Fiori 2, Emanuele Miraglia del Giudice 1, Alberta Lucchese 2,\*, Alma Nunzia Olivieri <sup>1</sup> and Rosario Serpico <sup>2</sup>**


**Abstract:** Scurvy is generated by lack of vitamin C; although it is considered a rare and past disease, scurvy continues to be detected in children with neurodevelopmental disorders and with selective diet habits. Identifying scurvy can be demanding due to the perceived rarity of the condition, and it can become a tricky diagnostic question given to the variety of nonspecific symptoms, including gingival manifestations. This study aims to identify most common clinical features in order to provide a complete picture of the signs and symptoms, and to offer clinicians the diagnostic tools for identifying patients suffering from scurvy. We present a case report of a child affected by scurvy; it has also been performed as a systematic review about scurvy in pediatric population. A search yielded 107 relevant studies since 1990. Most of the identified cases have shown oral, musculoskeletal and cutaneous manifestation that improved within a few days of starting vitamin C therapy. Identifying scurvy's characteristic clinical features allows a timely diagnosis, thus avoiding invasive investigations. Pediatric dentists should possess adequate knowledge and experience to identify the main characteristics of scurvy. This can help facilitate a prompt diagnosis in order to provide timely intervention to the patient that is relatively ease and safe.

**Keywords:** clinical manifestations; gingival disorders; oral scurvy; scurvy; vitamin C deficiency
