*4.4. Tumor Xenograft Mouse Models*

A549 and H1299 human lung cancer cell xenografts were established by *s.c.* implantation of <sup>2</sup> <sup>×</sup> <sup>10</sup><sup>6</sup> cultured cells into the thigh of the right hind leg of six-week-old mice. When tumor volumes had reached approximately 100 mm<sup>3</sup> , KJ-28d (10 mg/kg) was administered *i.p.* once per 2 or 3 days for seven times in total. All animal experiments were reviewed and approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological and Medical Sciences (kirams2018-0063, 2018).
