*Review* **High-Density Lipoproteins and Mediterranean Diet: A Systematic Review**

**Elena Grao-Cruces 1, Lourdes M. Varela 2,3,\*, Maria E. Martin 4, Beatriz Bermudez <sup>4</sup> and Sergio Montserrat-de la Paz <sup>1</sup>**


**Abstract:** Cardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies in CVD secondary prevention and the lack of association between HDL-C and the risk of CVD. Recent evidences suggest that HDL composition and functionality could be modulated by diet. The purpose of this systematic review was to investigate the effect of Mediterranean diet (MD) on changes in HDL structure and functionality in humans. A comprehensive search was conducted in four databases (PubMed, Scopus, Cochrane library and Web of Science) and 13 records were chosen. MD showed favorable effects on HDL functionality, particularly by improving HDL cholesterol efflux capacity and decreasing HDL oxidation. In addition, HDL composition and size were influenced by MD. Thus, MD is a protective factor against CVD associated with the improvement of HDL quality and the prevention of HDL dysfunctionality.

**Keywords:** high-density lipoprotein; lipidome; proteome; Mediterranean diet; olive oil
