*2.2. Imaging Protocol*

CEM was acquired with the dual-energy mammography system (Hologic's Selenia® Dimensions® Unit, Bedford, MA, USA) as reported in our previous studies [43]. Two minutes after the administration of 1.5 mL/kg body weight of iodinated contrast medium (Visipaque 320; GE Healthcare, Inc., Princeton, NJ, USA) at a rate of 2–3 mL/s, each woman was placed in a CC view. Four and eight minutes after administration of the contrast agent, each breast was compressed in the MLO view: early MLO and late MLO views, respectively.

DCE-MRI was acquired with a 1.5T MR scanner (Magnetom Symphony; Siemens Medical System, Erlangen, Germany) equipped with a dedicated breast coil with 16 channels. Scan settings are reported in our previous study [44]: one series before and nine series after the automatic intravenous injection of 0.1 mmol/kg body weight of a positive paramagnetic contrast material (Gd-DOTA; Dotarem, Guerbet, Roissy CdG CEDEX, France) were acquired.
