**Preface to "Zirconia and Innovative Biomaterials for Dental and Biomedical Applications"**

The use of zirconia in the biomedical field was initiated in the early 1970s, and the application of zirconia as a prosthetic material in dental-related applications was unlocked in the 1990s. Very recently, many scholars established the use of zirconia in the dental and biomedical field as an implant and as a scaffold. Thus, zirconia and zirconia-based materials have a wide range of applications in the biomedical and dentistry fields owing to their excellent mechanical properties, aesthetics, and biocompatibility. This Special Issue critically explores the art and state of zirconia surface treatments (mechanical/chemical/physical), which are a significant challenge in implantology in designing implant biomaterial using advanced technologies which have evolved rapidly to enrich the biological and osteointegration process of dental implants. The surface characteristics are proposed to improve the capacity of anchorage into the bone which determines the long-term clinical success rate. In addition, digital technology (CAD/CAM and 3D printing) in dentistry plays a crucial role in the fabrication of dental restorations and prostheses because of its efficient manufacturing process with high accuracy in a short time. The perfectibility of technology and the suitability of materials are considered the ultimate requisite for the future.

With an increase in age-related pathologies and associated illnesses worldwide, there is a necessity for the advancement of biomaterials to substitute tissue loss and boost regenerative mechanisms, as well as to ensure the healing process. Bioceramics, polymers, and metals are such materials that have been used to repair and restore bone and dental defects, especially for the reconstruction/regeneration of hard tissues. To achieve three-dimensional tissue regeneration, the porous scaffold with multifunctional properties was fabricated using additive manufacturing and conventional techniques.

> **Sangwon Park and John G. Fisher** *Editors*
