*Review Opuntia* **genus in Human Health: A Comprehensive Summary on Its Pharmacological, Therapeutic and Preventive Properties. Part 1**

**Eduardo Madrigal-Santillán 1,\*, Jacqueline Portillo-Reyes 1, Eduardo Madrigal-Bujaidar 2, Manuel Sánchez-Gutiérrez 3, Paola E. Mercado-Gonzalez 3, Jeannett A. Izquierdo-Vega 3, Nancy Vargas-Mendoza 1, Isela Álvarez-González 2, Tomás Fregoso-Aguilar 2, Luis Delgado-Olivares 3, Ánge<sup>l</sup> Morales-González 4, Liliana Anguiano-Robledo 1 and José A. Morales-González 1,\***


**Abstract:** *Opuntia* spp. is a diverse and widely distributed genus in Africa, Asia, Australia, and America. Mexico has the largest number of wild species; mainly *O. streptacantha, O. hyptiacantha, O. albicarpa, O. megacantha and O. ficus-indica.* The latter being the most cultivated and domesticated species. Throughout history, plants and their phytochemicals have played an important role in health care and *Opuntia* spp. has shown a high nutritional, medicinal, pharmaceutical, and economic impacts. Its main bioactive compounds include pigments (carotenoids, betalains and betacyanins), vitamins, flavonoids (isorhamnetin, kaempferol, quercetin) and phenolic compounds. Together, they favor the different plant parts and are considered phytochemically important and associated with control, progression and prevention of some chronic and infectious diseases. This first review (Part 1), compiles information from published research (in vitro, in vivo, and clinical studies) on its preventive effects against atherosclerotic cardiovascular diseases, diabetes and obesity, hepatoprotection, effects on human infertility and chemopreventive and/or antigenotoxic capacity. The aim is to provide scientific evidences of its beneficial properties and to encourage health professionals and researchers to expand studies on the pharmacological and therapeutic effects of *Opuntia* spp.

**Keywords:** *Opuntia* spp.; phytochemicals; biological activities; antioxidant capacity; chemopreventive effect
