*2.1. Study Design*

This was a prospective quasi-experimental study (ClinicalTrials.gov: NCT04571450). This research was approved by the Human Research Ethics Committee at the Hospital Universitario de Sagunto and followed the ethical guidelines established in the Declaration of Helsinki. The study describes the 3-year follow-up of 29 patients who already received an intervention with the 'Living Better' program in 2018 (*n* = 105) [17], as well as the result of completing the same program for a second time (reintervention) with the aim of helping to minimize the negative impact of the COVID-19 pandemic on lifestyle. To analyze the

long-term effects of the program, we used the follow-up values obtained at the end of the first study as our starting point (Time 0) [17], which was carried out 9 months after this intervention. We also used the different variables analyzed in 2018 and recorded shortly before the start of the second intervention (Time 1), 21 months later than Time 0. Once this evaluation was completed, the participants started the 3-month online reintervention with the 'Living Better' program. Finally, in order to understand the impact of this second intervention on the health of the participants, all the variables were recorded again at the end of the program (Time 2) (Figure 1). Of note, all the patients were assessed within 3 days at the different study timepoints.

**Figure 1.** Measurements at trial profile (Time 0, Time 1, and Time 2). Figure 1 shows the time periods when assessments and reintervention were carried out, along the 3-year follow-up.
