*2.1. Chemistry*

All chemicals used were obtained from commercial sources (Merck, Acros, Syngene) and were used as supplied without further purification. Merck silica gel 60 (230–400 mesh) and Merck aluminum oxide (activity II–III, according to Brockmann) were used for chromatographic columns with the indicated solvents. Merck TLC plates (silica gel 60 F254 and aluminum oxide F254) were used to monitor all operations, and then compounds were visualized under UV light (254 and 365 nm) and/or stained with the relevant reagents. The yields were not optimized and refer to the purified products. 13C NMR and 1H NMR spectra were recorded on a Bruker Avance III NMR 400 spectrometer with reference to tetramethylsilane (TMS) in the indicated solvent. Chemical shift values are expressed in parts per million (ppm). Coupling constants (*J*) are reported in hertz with signal multiplicities indicated as singlet (s), doublet (d), triplet (t), quadruplet (q) and multiplet (m). When specified, ChemDraw Professional 16.0 was used to generate systematic compound names following IUPAC conventions. Detailed synthetic procedures and spectroscopic data are reported in the Supplementary Materials.
