*Review* **Immune Regulation of Heme Oxygenase-1 in Allergic Airway Inflammation**

**Zhenwei Xia 1,\* and Wenwei Zhong 2,\***


**Abstract:** Heme oxygenase-1 (HO-1) is not only a rate-limiting enzyme in heme metabolism but is also regarded as a protective protein with an immunoregulation role in asthmatic airway inflammation. HO-1 exerts an anti-inflammation role in different stages of airway inflammation via regulating various immune cells, such as dendritic cells, mast cells, basophils, T cells, and macrophages. In addition, the immunoregulation role of HO-1 may differ according to subcellular locations.

**Keywords:** heme oxygenase-1; asthma; airway inflammation; immunoregulation
