**3. Results**

#### *3.1. Infections*

Three or more yearly upper respiratory infections (URI) (rhinorrhea, nasal congestion, and productive cough), requiring antibiotic therapy for at least two consecutive years, were recorded in 18 (34.6%) of the SIgED patients. Sixteen patients (30.7%) had suffered one or more episodes of pneumonia (range 1 to 3). Median IgG, IgM, and IgA levels were not significantly different in patients with or without URI or pneumonia (data not shown). In two patients, chronic respiratory infection with *M. avium* complex was identified. Recurrent episodes of otitis were recorded in four patients. Three patients had suffered from herpesvirus infections, and one had suffered from chronic pyelonephritis.
