**4. Autoimmunity in Disorders of T-Cell Central Tolerance**

The immunologic tolerance for T cells is reached through the process of central negative selection of self-reactive T cell progenitors, the peripheral induction of anergy of cells escaping central tolerance, and the action of Tregs [69]. Autoimmune polyendocrine syndrome (APS-1) and 22q11.2 deletion syndrome (22q11.2DS) represent two paradigmatic examples of autoimmunity caused by impaired central negative selection of T cells.
