*2.8. Statistical Analysis*

Statistical analysis was performed using SigmaPlot 14.0 software (Systat Software, Erkrath, Germany). All qPCR data were subjected to logarithmic tranformation and statistically significant differences were calculated by Student's *t*-test in the case of single comparison analyses. If applicable, *p*-values were subjected to False Discovery Rate (FDR) correction [46]. Results were considered as significant at *p* < 0.05 and are indicated in the graphs by \* *p* < 0.05, \*\* *p* < 0.01, \*\*\* *p* < 0.001.

#### **3. Results**
