*4.4. Data Analysis*

The data obtained were analyzed using PEAKS XPro software (BSI, North Waterloo, ON, Canada) according to the following parameters: parent mass error tolerance −20 ppm; fragment mass error tolerance −0.03 Da; enzyme—trypsin; missed cleavages—3; fixed modifications—Carbamidomethyl (C); variable modifications—Oxidation (M), Acetylation (N-term). The search was carried out using the SwissProt Human database. False discovery rate threshold was set to 0.01. Scripts written in R version 3.3.3 [58] and RStudio 1.383 [57] were used for statistical processing of the results.
