*4.8. Statistics*

Statistical analysis was performed using GraphPad 5.04 software. Study groups were analyzed by two-way ANOVA using Sidak's multiple comparisons post hoc test. Data are presented as mean ± SD. *p* values < 0.05 were considered statistically significant.

**Supplementary Materials:** The following are available online at: https://www.mdpi.com/article/ 10.3390/ijms23126870/s1.

**Author Contributions:** Conceptualization, M.G, D.T. and L.M.; Data curation, Z.Z.; Formal analysis, Z.Z. and Y.X.; Funding acquisition, M.S., B.N. and M.G.; Investigation, Z.Z. and Y.X.; Methodology, Z.Z., U.K., M.S., B.N. and M.-B.K.; Project administration, M.G., D.T. and L.M.; Resources, U.K., T.G., M.G. and L.M.; Software, Z.Z., D.T. and L.M.; Supervision, M.G., D.T. and L.M.; Validation, D.T. and L.M.; Writing—original draft, Z.Z.; Writing—review and editing, M.G., D.T. and L.M. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors made substantial contributions to conception, design, drafting and completion of the article. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by the Deutsche Forschungsgemeinschaft (DFG) to M.G. (GO766/18-2, GO 766/12-3, SFB 1365), B.N. (NU 53/12-2) and M.S. (TRR 152) and Werner Jackstädt-Stiftung.

**Institutional Review Board Statement:** The animal study protocol was approved by the Berlin Animal Review Board, Berlin, Germany and followed the restrictions in the Berlin State Office for Health and Social Affairs (Landesamt für Gesundheit und Soziales, LaGeSo) (license No. G0175/18, 11 Sep. 2018). All experiments were performed in accordance with ARRIVE guidelines.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Represented data are publicly archived datasets. For further information, please contact the corresponding author.

**Acknowledgments:** We thank Mario Kaßmann for his administrative support. We thank Jana Czychi, Gabriele N'diaye, and Juliane Ulrich for their technical help. We acknowledge financial support from the Open Access Publication Fund of Charité—Universitätsmedizin Berlin and the German Research Foundation (DFG).

**Conflicts of Interest:** The authors declare no conflict of interest.
