**7. MBG Action on the Nervous System**

In addition to CV and renal effects, the action of sodium and MBG also occurs at the level of the central nervous system, through channels in the glial cells of the supraoptic and paraventricular nuclei, where the detection of osmolarity and salt takes place through a new isoform of the sodium Nax channels [156]. MBG also acts on Amyloid Precursor Protein (APP), apolipoprotein E (APOE) and Connective Tissue Growth factors (CTGFs). Specifically, APP triggers a cascade of neurodegenerative events, such as synaptic dysfunctions, the genesis of neurofibrillary tangles and neuronal death. New findings show that, after MBG infusion, downregulation of APP mRNA expression in vivo in DSS rats is present [17,157].
