*4.3. Serum and Blood Chemistry*

Mice were sacrificed and serum samples were collected within 4 h after the last rhGH or vehicle injection. VetScan® Comprehensive Diagnostic Profile reagent rotor and the VetScan Chemistry Analyzer (Union City, CA, USA) were used for quantitative determination of BUN and serum creatine concentration (Supplemental Table S1). Concentrations of serum GH in mice were analyzed using commercially available ELISA kits according to the manufacturer's protocols (Supplemental Table S1).
